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Inhibition of polyploidization in Pten‐deficient livers reduces steatosis
The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver‐specific deletion of Pten in mice results in the hyper‐activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid accumulation (steatosis) and formation of hep...
Autores principales: | Moreno, Eva, Matondo, Augustine B., Bongiovanni, Laura, van de Lest, Chris H. A., Molenaar, Martijn R., Toussaint, Mathilda J. M., van Essen, Saskia C., Houweling, Martin, Helms, J. Bernd, Westendorp, Bart, de Bruin, Alain |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826152/ https://www.ncbi.nlm.nih.gov/pubmed/35924448 http://dx.doi.org/10.1111/liv.15384 |
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