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Inhibition of polyploidization in Pten‐deficient livers reduces steatosis

The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver‐specific deletion of Pten in mice results in the hyper‐activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid accumulation (steatosis) and formation of hep...

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Detalles Bibliográficos
Autores principales:	Moreno, Eva, Matondo, Augustine B., Bongiovanni, Laura, van de Lest, Chris H. A., Molenaar, Martijn R., Toussaint, Mathilda J. M., van Essen, Saskia C., Houweling, Martin, Helms, J. Bernd, Westendorp, Bart, de Bruin, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Metabolic & Toxic Liver Diseases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826152/ https://www.ncbi.nlm.nih.gov/pubmed/35924448 http://dx.doi.org/10.1111/liv.15384

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