Glycolaldehyde as a Bio‐Based C(1) Building Block for Selective N‐Formylation of Secondary Amines

Biomass derived glycolaldehyde was employed as C1 building block for the N‐formylation of secondary amines using air as oxidant. The reaction is atom economic, highly selective and proceeds under catalyst free conditions. This strategy can be used for the synthesis of cyclic and acyclic formylamines...

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Detalles Bibliográficos
Autores principales: Flynn, Matthew T., Liu, Xin, Dell'Acqua, Andrea, Rabeah, Jabor, Brückner, Angelika, Baráth, Eszter, Tin, Sergey, de Vries, Johannes G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826180/
https://www.ncbi.nlm.nih.gov/pubmed/35947792
http://dx.doi.org/10.1002/cssc.202201264
Descripción
Sumario:Biomass derived glycolaldehyde was employed as C1 building block for the N‐formylation of secondary amines using air as oxidant. The reaction is atom economic, highly selective and proceeds under catalyst free conditions. This strategy can be used for the synthesis of cyclic and acyclic formylamines, including DMF. Mechanistic studies suggest a radical oxidation pathway.

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