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Phen‐DC(3) Induces Refolding of Human Telomeric DNA into a Chair‐Type Antiparallel G‐Quadruplex through Ligand Intercalation

Human telomeric G‐quadruplex DNA structures are attractive anticancer drug targets, but the target's polymorphism complicates the drug design: different ligands prefer different folds, and very few complexes have been solved at high resolution. Here we report that Phen‐DC(3), one of the most pr...

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Detalles Bibliográficos
Autores principales:	Ghosh, Anirban, Trajkovski, Marko, Teulade‐Fichou, Marie‐Paule, Gabelica, Valérie, Plavec, Janez
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826182/ https://www.ncbi.nlm.nih.gov/pubmed/35993443 http://dx.doi.org/10.1002/anie.202207384

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