Direct Synthesis of 3‐Aryl Substituted Isocoumarins and Phthalides through Palladium Acetate Catalyzed C(sp ( 2 ))−H Activation in Ionic Liquids

A novel Pd‐catalysed oxidative coupling between benzoic acids and vinylarenes or acrylates to furnish isocoumarins and phthalides is reported. The reaction proceeds smoothly in molten tetrabutylammonium acetate via a selective C−H bond activation, with very low percentage of ligand‐free palladium ac...

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Detalles Bibliográficos
Autores principales: Aloia, Andrea, Casiello, Michele, D'Accolti, Lucia, Fusco, Caterina, Nacci, Angelo, Monopoli, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826210/
https://www.ncbi.nlm.nih.gov/pubmed/35997238
http://dx.doi.org/10.1002/chem.202202350
Descripción
Sumario:A novel Pd‐catalysed oxidative coupling between benzoic acids and vinylarenes or acrylates to furnish isocoumarins and phthalides is reported. The reaction proceeds smoothly in molten tetrabutylammonium acetate via a selective C−H bond activation, with very low percentage of ligand‐free palladium acetate as the catalyst, under atmospheric pressure of oxygen. Sub‐stoichiometric amount of copper acetate is also required as a reoxidant for the palladium.

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