Cargando…
A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dime...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826239/ https://www.ncbi.nlm.nih.gov/pubmed/35989251 http://dx.doi.org/10.1002/anie.202210043 |
_version_ | 1784866803922501632 |
---|---|
author | Gallego, Iván Ramos‐Soriano, Javier Méndez‐Ardoy, Alejandro Cabrera‐González, Justo Lostalé‐Seijo, Irene Illescas, Beatriz M. Reina, Jose J. Martín, Nazario Montenegro, Javier |
author_facet | Gallego, Iván Ramos‐Soriano, Javier Méndez‐Ardoy, Alejandro Cabrera‐González, Justo Lostalé‐Seijo, Irene Illescas, Beatriz M. Reina, Jose J. Martín, Nazario Montenegro, Javier |
author_sort | Gallego, Iván |
collection | PubMed |
description | Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials. |
format | Online Article Text |
id | pubmed-9826239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98262392023-01-09 A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition Gallego, Iván Ramos‐Soriano, Javier Méndez‐Ardoy, Alejandro Cabrera‐González, Justo Lostalé‐Seijo, Irene Illescas, Beatriz M. Reina, Jose J. Martín, Nazario Montenegro, Javier Angew Chem Int Ed Engl Research Articles Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials. John Wiley and Sons Inc. 2022-09-06 2022-10-10 /pmc/articles/PMC9826239/ /pubmed/35989251 http://dx.doi.org/10.1002/anie.202210043 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Gallego, Iván Ramos‐Soriano, Javier Méndez‐Ardoy, Alejandro Cabrera‐González, Justo Lostalé‐Seijo, Irene Illescas, Beatriz M. Reina, Jose J. Martín, Nazario Montenegro, Javier A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition |
title | A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition |
title_full | A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition |
title_fullStr | A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition |
title_full_unstemmed | A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition |
title_short | A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition |
title_sort | 3d peptide/[60]fullerene hybrid for multivalent recognition |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826239/ https://www.ncbi.nlm.nih.gov/pubmed/35989251 http://dx.doi.org/10.1002/anie.202210043 |
work_keys_str_mv | AT gallegoivan a3dpeptide60fullerenehybridformultivalentrecognition AT ramossorianojavier a3dpeptide60fullerenehybridformultivalentrecognition AT mendezardoyalejandro a3dpeptide60fullerenehybridformultivalentrecognition AT cabreragonzalezjusto a3dpeptide60fullerenehybridformultivalentrecognition AT lostaleseijoirene a3dpeptide60fullerenehybridformultivalentrecognition AT illescasbeatrizm a3dpeptide60fullerenehybridformultivalentrecognition AT reinajosej a3dpeptide60fullerenehybridformultivalentrecognition AT martinnazario a3dpeptide60fullerenehybridformultivalentrecognition AT montenegrojavier a3dpeptide60fullerenehybridformultivalentrecognition AT gallegoivan 3dpeptide60fullerenehybridformultivalentrecognition AT ramossorianojavier 3dpeptide60fullerenehybridformultivalentrecognition AT mendezardoyalejandro 3dpeptide60fullerenehybridformultivalentrecognition AT cabreragonzalezjusto 3dpeptide60fullerenehybridformultivalentrecognition AT lostaleseijoirene 3dpeptide60fullerenehybridformultivalentrecognition AT illescasbeatrizm 3dpeptide60fullerenehybridformultivalentrecognition AT reinajosej 3dpeptide60fullerenehybridformultivalentrecognition AT martinnazario 3dpeptide60fullerenehybridformultivalentrecognition AT montenegrojavier 3dpeptide60fullerenehybridformultivalentrecognition |