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A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition

Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dime...

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Autores principales: Gallego, Iván, Ramos‐Soriano, Javier, Méndez‐Ardoy, Alejandro, Cabrera‐González, Justo, Lostalé‐Seijo, Irene, Illescas, Beatriz M., Reina, Jose J., Martín, Nazario, Montenegro, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826239/
https://www.ncbi.nlm.nih.gov/pubmed/35989251
http://dx.doi.org/10.1002/anie.202210043
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author Gallego, Iván
Ramos‐Soriano, Javier
Méndez‐Ardoy, Alejandro
Cabrera‐González, Justo
Lostalé‐Seijo, Irene
Illescas, Beatriz M.
Reina, Jose J.
Martín, Nazario
Montenegro, Javier
author_facet Gallego, Iván
Ramos‐Soriano, Javier
Méndez‐Ardoy, Alejandro
Cabrera‐González, Justo
Lostalé‐Seijo, Irene
Illescas, Beatriz M.
Reina, Jose J.
Martín, Nazario
Montenegro, Javier
author_sort Gallego, Iván
collection PubMed
description Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.
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spelling pubmed-98262392023-01-09 A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition Gallego, Iván Ramos‐Soriano, Javier Méndez‐Ardoy, Alejandro Cabrera‐González, Justo Lostalé‐Seijo, Irene Illescas, Beatriz M. Reina, Jose J. Martín, Nazario Montenegro, Javier Angew Chem Int Ed Engl Research Articles Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials. John Wiley and Sons Inc. 2022-09-06 2022-10-10 /pmc/articles/PMC9826239/ /pubmed/35989251 http://dx.doi.org/10.1002/anie.202210043 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Gallego, Iván
Ramos‐Soriano, Javier
Méndez‐Ardoy, Alejandro
Cabrera‐González, Justo
Lostalé‐Seijo, Irene
Illescas, Beatriz M.
Reina, Jose J.
Martín, Nazario
Montenegro, Javier
A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
title A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
title_full A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
title_fullStr A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
title_full_unstemmed A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
title_short A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
title_sort 3d peptide/[60]fullerene hybrid for multivalent recognition
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826239/
https://www.ncbi.nlm.nih.gov/pubmed/35989251
http://dx.doi.org/10.1002/anie.202210043
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