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The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018
OBJECTIVE: To determine the levels and patterns of resistance to first‐ and second‐line anti‐tuberculosis (TB) drugs among new and previously treated sputum smear positive pulmonary TB (PTB) patients. METHODS: We conducted a nationally representative cross‐sectional facility‐based survey in June 201...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826299/ https://www.ncbi.nlm.nih.gov/pubmed/36089572 http://dx.doi.org/10.1111/tmi.13814 |
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author | Mutayoba, Beatrice Kemilembe Ershova, Julia Lyamuya, Eligius Hoelscher, Michael Heinrich, Norbert Kilale, Andrew Martin Range, Nyagosya Segere Ngowi, Benard James Ntinginya, Nyanda Elias Mfaume, Saidi Mwinjuma Nkiligi, Emmanuel Doulla, Basra Lyimo, Johnson Kisonga, Riziki Kingalu, Amri Lema, Yakobo Kondo, Zuwena Pletschette, Michel |
author_facet | Mutayoba, Beatrice Kemilembe Ershova, Julia Lyamuya, Eligius Hoelscher, Michael Heinrich, Norbert Kilale, Andrew Martin Range, Nyagosya Segere Ngowi, Benard James Ntinginya, Nyanda Elias Mfaume, Saidi Mwinjuma Nkiligi, Emmanuel Doulla, Basra Lyimo, Johnson Kisonga, Riziki Kingalu, Amri Lema, Yakobo Kondo, Zuwena Pletschette, Michel |
author_sort | Mutayoba, Beatrice Kemilembe |
collection | PubMed |
description | OBJECTIVE: To determine the levels and patterns of resistance to first‐ and second‐line anti‐tuberculosis (TB) drugs among new and previously treated sputum smear positive pulmonary TB (PTB) patients. METHODS: We conducted a nationally representative cross‐sectional facility‐based survey in June 2017–July 2018 involving 45 clusters selected based on probability proportional to size. The survey aimed to determine the prevalence of anti‐TB drug resistance and associated risk factors among smear positive PTB patients in Tanzania. Sputum samples were examined using smear microscopy, Xpert MTB/RIF, culture and drug susceptibility testing (DST). Logistic regression was used to account for missing data and sampling design effects on the estimates and their standard errors. RESULTS: We enrolled 1557 TB patients, including 1408 (90.4%) newly diagnosed and 149 (9.6%) previously treated patients. The prevalence of multidrug‐resistant TB (MDR‐TB) was 0.85% [95% confidence interval (CI): 0.4–1.3] among new cases and 4.6% (95% CI: 1.1–8.2) among previously treated cases. The prevalence of Mycobacterium tuberculosis strains resistant to any of the four first‐line anti‐TB drugs (isoniazid, rifampicin, streptomycin and ethambutol) was 1.7% among new TB patients and 6.5% among those previously treated. Drug resistance to all first‐line drugs was similar (0.1%) in new and previously treated patients. None of the isolates displayed poly‐resistance or extensively drug‐resistant TB (XDR‐TB). The only risk factor for MDR‐TB was history of previous TB treatment (odds ratio = 5.7, 95% CI: 1.9–17.2). CONCLUSION: The burden of MDR‐TB in the country was relatively low with no evidence of XDR‐TB. Given the overall small number of MDR‐TB cases in this survey, it will be beneficial focusing efforts on intensified case detection including universal DST. |
format | Online Article Text |
id | pubmed-9826299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98262992023-01-09 The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 Mutayoba, Beatrice Kemilembe Ershova, Julia Lyamuya, Eligius Hoelscher, Michael Heinrich, Norbert Kilale, Andrew Martin Range, Nyagosya Segere Ngowi, Benard James Ntinginya, Nyanda Elias Mfaume, Saidi Mwinjuma Nkiligi, Emmanuel Doulla, Basra Lyimo, Johnson Kisonga, Riziki Kingalu, Amri Lema, Yakobo Kondo, Zuwena Pletschette, Michel Trop Med Int Health Research Articles OBJECTIVE: To determine the levels and patterns of resistance to first‐ and second‐line anti‐tuberculosis (TB) drugs among new and previously treated sputum smear positive pulmonary TB (PTB) patients. METHODS: We conducted a nationally representative cross‐sectional facility‐based survey in June 2017–July 2018 involving 45 clusters selected based on probability proportional to size. The survey aimed to determine the prevalence of anti‐TB drug resistance and associated risk factors among smear positive PTB patients in Tanzania. Sputum samples were examined using smear microscopy, Xpert MTB/RIF, culture and drug susceptibility testing (DST). Logistic regression was used to account for missing data and sampling design effects on the estimates and their standard errors. RESULTS: We enrolled 1557 TB patients, including 1408 (90.4%) newly diagnosed and 149 (9.6%) previously treated patients. The prevalence of multidrug‐resistant TB (MDR‐TB) was 0.85% [95% confidence interval (CI): 0.4–1.3] among new cases and 4.6% (95% CI: 1.1–8.2) among previously treated cases. The prevalence of Mycobacterium tuberculosis strains resistant to any of the four first‐line anti‐TB drugs (isoniazid, rifampicin, streptomycin and ethambutol) was 1.7% among new TB patients and 6.5% among those previously treated. Drug resistance to all first‐line drugs was similar (0.1%) in new and previously treated patients. None of the isolates displayed poly‐resistance or extensively drug‐resistant TB (XDR‐TB). The only risk factor for MDR‐TB was history of previous TB treatment (odds ratio = 5.7, 95% CI: 1.9–17.2). CONCLUSION: The burden of MDR‐TB in the country was relatively low with no evidence of XDR‐TB. Given the overall small number of MDR‐TB cases in this survey, it will be beneficial focusing efforts on intensified case detection including universal DST. John Wiley and Sons Inc. 2022-09-11 2022-10 /pmc/articles/PMC9826299/ /pubmed/36089572 http://dx.doi.org/10.1111/tmi.13814 Text en © 2022 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Mutayoba, Beatrice Kemilembe Ershova, Julia Lyamuya, Eligius Hoelscher, Michael Heinrich, Norbert Kilale, Andrew Martin Range, Nyagosya Segere Ngowi, Benard James Ntinginya, Nyanda Elias Mfaume, Saidi Mwinjuma Nkiligi, Emmanuel Doulla, Basra Lyimo, Johnson Kisonga, Riziki Kingalu, Amri Lema, Yakobo Kondo, Zuwena Pletschette, Michel The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 |
title | The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 |
title_full | The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 |
title_fullStr | The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 |
title_full_unstemmed | The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 |
title_short | The second national anti‐tuberculosis drug resistance survey in Tanzania, 2017–2018 |
title_sort | second national anti‐tuberculosis drug resistance survey in tanzania, 2017–2018 |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826299/ https://www.ncbi.nlm.nih.gov/pubmed/36089572 http://dx.doi.org/10.1111/tmi.13814 |
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