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In Vitro and In Vivo Pharmacological Profiles of DS‐1211, a Novel Potent, Selective, and Orally Bioavailable Tissue‐Nonspecific Alkaline Phosphatase Inhibitor

Inhibition of tissue‐nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous pyrophosphate (PPi). DS‐1211 is a potent and selective novel small molecule TNAP inhibitor with well‐characterized pharmacokinetics (PKs) in rodent and monkey. Herein,...

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Detalles Bibliográficos
Autores principales:	Soma, Kaori, Izumi, Masanori, Yamamoto, Yuko, Miyazaki, Shojiro, Watanabe, Kengo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826446/ https://www.ncbi.nlm.nih.gov/pubmed/36054139 http://dx.doi.org/10.1002/jbmr.4680

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