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Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice

BACKGROUND: Previous studies have shown controversial results regarding the pro- or anticonvulsant effects of tramadol. Additionally, the underlying mechanism of seizure induction or alleviation by tramadol has not been fully understood. In the current study, the effects of tramadol on pentylenetetr...

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Autores principales: Zahir, Mazyar, Rashidian, Amir, Hoseini, Mohsen, Akbarian, Reyhaneh, Chamanara, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826747/
https://www.ncbi.nlm.nih.gov/pubmed/36660072
http://dx.doi.org/10.3934/Neuroscience.2022024
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author Zahir, Mazyar
Rashidian, Amir
Hoseini, Mohsen
Akbarian, Reyhaneh
Chamanara, Mohsen
author_facet Zahir, Mazyar
Rashidian, Amir
Hoseini, Mohsen
Akbarian, Reyhaneh
Chamanara, Mohsen
author_sort Zahir, Mazyar
collection PubMed
description BACKGROUND: Previous studies have shown controversial results regarding the pro- or anticonvulsant effects of tramadol. Additionally, the underlying mechanism of seizure induction or alleviation by tramadol has not been fully understood. In the current study, the effects of tramadol on pentylenetetrazole (PTZ)-induced seizure and the possible involvement of the N-methyl-D-aspartate (NMDA) pathway were assessed in mice. METHODS: Male Naval Medical Research Institute (NMRI) mice were treated with intravenous infusion of PTZ in order to induce clonic seizures and determine seizure threshold. Tramadol was injected intraperitoneally (0.1–150 mg/kg) 30 minutes prior to elicitation of seizures. The possible effects of intraperitoneal injections of NMDA receptor antagonists, ketamine (0.5 mg/kg) and MK-801 (0.5 mg/kg) on the anticonvulsant property of tramadol were investigated subsequently. RESULTS: Tramadol (1–100 mg/kg) increased PTZ-induced seizure threshold in a dose-dependent, time-independent manner, with optimal anticonvulsant effect at a dose of 100 mg/kg. Acute administration of either ketamine (0.5 mg/kg) or MK-801 (0.5 mg/kg) potentiated the anticonvulsant effect of a subeffective dose of tramadol (0.3 mg/kg). CONCLUSION: These results suggest a possible role of the NMDA pathway in the anticonvulsant effect of tramadol.
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spelling pubmed-98267472023-01-18 Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice Zahir, Mazyar Rashidian, Amir Hoseini, Mohsen Akbarian, Reyhaneh Chamanara, Mohsen AIMS Neurosci Research Article BACKGROUND: Previous studies have shown controversial results regarding the pro- or anticonvulsant effects of tramadol. Additionally, the underlying mechanism of seizure induction or alleviation by tramadol has not been fully understood. In the current study, the effects of tramadol on pentylenetetrazole (PTZ)-induced seizure and the possible involvement of the N-methyl-D-aspartate (NMDA) pathway were assessed in mice. METHODS: Male Naval Medical Research Institute (NMRI) mice were treated with intravenous infusion of PTZ in order to induce clonic seizures and determine seizure threshold. Tramadol was injected intraperitoneally (0.1–150 mg/kg) 30 minutes prior to elicitation of seizures. The possible effects of intraperitoneal injections of NMDA receptor antagonists, ketamine (0.5 mg/kg) and MK-801 (0.5 mg/kg) on the anticonvulsant property of tramadol were investigated subsequently. RESULTS: Tramadol (1–100 mg/kg) increased PTZ-induced seizure threshold in a dose-dependent, time-independent manner, with optimal anticonvulsant effect at a dose of 100 mg/kg. Acute administration of either ketamine (0.5 mg/kg) or MK-801 (0.5 mg/kg) potentiated the anticonvulsant effect of a subeffective dose of tramadol (0.3 mg/kg). CONCLUSION: These results suggest a possible role of the NMDA pathway in the anticonvulsant effect of tramadol. AIMS Press 2022-11-10 /pmc/articles/PMC9826747/ /pubmed/36660072 http://dx.doi.org/10.3934/Neuroscience.2022024 Text en © 2022 the Author(s), licensee AIMS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) )
spellingShingle Research Article
Zahir, Mazyar
Rashidian, Amir
Hoseini, Mohsen
Akbarian, Reyhaneh
Chamanara, Mohsen
Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice
title Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice
title_full Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice
title_fullStr Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice
title_full_unstemmed Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice
title_short Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice
title_sort pharmacological evidence for the possible involvement of the nmda receptor pathway in the anticonvulsant effect of tramadol in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826747/
https://www.ncbi.nlm.nih.gov/pubmed/36660072
http://dx.doi.org/10.3934/Neuroscience.2022024
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