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Depression and Parkinson's disease: a Chicken-Egg story
Parkinson's disease (PD) is a neurodegenerative disease, however, besides the motor symptoms, such as rest tremor, hypokinesia, postural instability and rigidity, PD patients have also non-motor symptoms, namely neuropsychiatric disorders. Apart from the required motor symptoms, psychopathologi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AIMS Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826748/ https://www.ncbi.nlm.nih.gov/pubmed/36660077 http://dx.doi.org/10.3934/Neuroscience.2022027 |
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author | Chakraborty, Ashok Diwan, Anil |
author_facet | Chakraborty, Ashok Diwan, Anil |
author_sort | Chakraborty, Ashok |
collection | PubMed |
description | Parkinson's disease (PD) is a neurodegenerative disease, however, besides the motor symptoms, such as rest tremor, hypokinesia, postural instability and rigidity, PD patients have also non-motor symptoms, namely neuropsychiatric disorders. Apart from the required motor symptoms, psychopathological symptoms are very common and include mood disorders, anxiety disorders, hallucinations, psychosis, cognitive deterioration and dementia. The underlying pathophysiological process in PD is mainly due to the loss of dopaminergic neural cells and thereby causes the shortage of nigrostriatal dopamine content in them. In addition, it may involve other neurotransmitter systems such as the noradrenergic, serotonergic, cholinergic and noradrenergic systems as well. Depression can result from any unhealthy conditions making the diagnosis a challenging task. The manifestation of depression associated with or without PD is inadequate. The co-occurrence of depression and PD often leads to the conceptual discussion on whether depressive symptoms appear before or after PD develops. This paper will discuss the conceptual mechanism of PD and depression. Keep in mind both conditions belong to two separate entities but share some similar aspects in their pathophysiology. |
format | Online Article Text |
id | pubmed-9826748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AIMS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98267482023-01-18 Depression and Parkinson's disease: a Chicken-Egg story Chakraborty, Ashok Diwan, Anil AIMS Neurosci Review Parkinson's disease (PD) is a neurodegenerative disease, however, besides the motor symptoms, such as rest tremor, hypokinesia, postural instability and rigidity, PD patients have also non-motor symptoms, namely neuropsychiatric disorders. Apart from the required motor symptoms, psychopathological symptoms are very common and include mood disorders, anxiety disorders, hallucinations, psychosis, cognitive deterioration and dementia. The underlying pathophysiological process in PD is mainly due to the loss of dopaminergic neural cells and thereby causes the shortage of nigrostriatal dopamine content in them. In addition, it may involve other neurotransmitter systems such as the noradrenergic, serotonergic, cholinergic and noradrenergic systems as well. Depression can result from any unhealthy conditions making the diagnosis a challenging task. The manifestation of depression associated with or without PD is inadequate. The co-occurrence of depression and PD often leads to the conceptual discussion on whether depressive symptoms appear before or after PD develops. This paper will discuss the conceptual mechanism of PD and depression. Keep in mind both conditions belong to two separate entities but share some similar aspects in their pathophysiology. AIMS Press 2022-11-23 /pmc/articles/PMC9826748/ /pubmed/36660077 http://dx.doi.org/10.3934/Neuroscience.2022027 Text en © 2022 the Author(s), licensee AIMS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ) |
spellingShingle | Review Chakraborty, Ashok Diwan, Anil Depression and Parkinson's disease: a Chicken-Egg story |
title | Depression and Parkinson's disease: a Chicken-Egg story |
title_full | Depression and Parkinson's disease: a Chicken-Egg story |
title_fullStr | Depression and Parkinson's disease: a Chicken-Egg story |
title_full_unstemmed | Depression and Parkinson's disease: a Chicken-Egg story |
title_short | Depression and Parkinson's disease: a Chicken-Egg story |
title_sort | depression and parkinson's disease: a chicken-egg story |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826748/ https://www.ncbi.nlm.nih.gov/pubmed/36660077 http://dx.doi.org/10.3934/Neuroscience.2022027 |
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