The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin

BACKGROUND: Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified. METHOD: A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated int...

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Autores principales: Lee, Ji Hae, Kweon, HaeYong, Oh, Ji-Hyeon, Kim, Seong-Gon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826769/
https://www.ncbi.nlm.nih.gov/pubmed/36617599
http://dx.doi.org/10.1186/s40902-022-00368-0
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author Lee, Ji Hae
Kweon, HaeYong
Oh, Ji-Hyeon
Kim, Seong-Gon
author_facet Lee, Ji Hae
Kweon, HaeYong
Oh, Ji-Hyeon
Kim, Seong-Gon
author_sort Lee, Ji Hae
collection PubMed
description BACKGROUND: Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified. METHOD: A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology. RESULTS: Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003). CONCLUSION: Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.
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spelling pubmed-98267692023-01-10 The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin Lee, Ji Hae Kweon, HaeYong Oh, Ji-Hyeon Kim, Seong-Gon Maxillofac Plast Reconstr Surg Research BACKGROUND: Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified. METHOD: A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology. RESULTS: Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003). CONCLUSION: Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts. Springer Nature Singapore 2023-01-09 /pmc/articles/PMC9826769/ /pubmed/36617599 http://dx.doi.org/10.1186/s40902-022-00368-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Lee, Ji Hae
Kweon, HaeYong
Oh, Ji-Hyeon
Kim, Seong-Gon
The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
title The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
title_full The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
title_fullStr The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
title_full_unstemmed The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
title_short The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
title_sort optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826769/
https://www.ncbi.nlm.nih.gov/pubmed/36617599
http://dx.doi.org/10.1186/s40902-022-00368-0
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