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Ribosome biogenesis in disease: new players and therapeutic targets

The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1, Myc, and noncoding RNA signaling pathways ar...

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Autores principales: Jiao, Lijuan, Liu, Yuzhe, Yu, Xi-Yong, Pan, Xiangbin, Zhang, Yu, Tu, Junchu, Song, Yao-Hua, Li, Yangxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826790/
https://www.ncbi.nlm.nih.gov/pubmed/36617563
http://dx.doi.org/10.1038/s41392-022-01285-4
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author Jiao, Lijuan
Liu, Yuzhe
Yu, Xi-Yong
Pan, Xiangbin
Zhang, Yu
Tu, Junchu
Song, Yao-Hua
Li, Yangxin
author_facet Jiao, Lijuan
Liu, Yuzhe
Yu, Xi-Yong
Pan, Xiangbin
Zhang, Yu
Tu, Junchu
Song, Yao-Hua
Li, Yangxin
author_sort Jiao, Lijuan
collection PubMed
description The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1, Myc, and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis. Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth. Myc is implicated in cancer development by enhancing RNA Pol II activity, leading to uncontrolled cancer cell growth. The deregulation of noncoding RNAs such as microRNAs, long noncoding RNAs, and circular RNAs is involved in developing blood, neurodegenerative diseases, and atherosclerosis. We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance. We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting, ribosome-stalling, and ribosome-collision. We summarize the role of ribosome biogenesis in the development of various diseases. Furthermore, we review the current clinical trials, prospective vaccines for COVID-19, and therapies targeting ribosome biogenesis in cancer, cardiovascular disease, aging, and neurodegenerative disease.
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spelling pubmed-98267902023-01-10 Ribosome biogenesis in disease: new players and therapeutic targets Jiao, Lijuan Liu, Yuzhe Yu, Xi-Yong Pan, Xiangbin Zhang, Yu Tu, Junchu Song, Yao-Hua Li, Yangxin Signal Transduct Target Ther Review Article The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1, Myc, and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis. Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth. Myc is implicated in cancer development by enhancing RNA Pol II activity, leading to uncontrolled cancer cell growth. The deregulation of noncoding RNAs such as microRNAs, long noncoding RNAs, and circular RNAs is involved in developing blood, neurodegenerative diseases, and atherosclerosis. We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance. We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting, ribosome-stalling, and ribosome-collision. We summarize the role of ribosome biogenesis in the development of various diseases. Furthermore, we review the current clinical trials, prospective vaccines for COVID-19, and therapies targeting ribosome biogenesis in cancer, cardiovascular disease, aging, and neurodegenerative disease. Nature Publishing Group UK 2023-01-09 /pmc/articles/PMC9826790/ /pubmed/36617563 http://dx.doi.org/10.1038/s41392-022-01285-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Jiao, Lijuan
Liu, Yuzhe
Yu, Xi-Yong
Pan, Xiangbin
Zhang, Yu
Tu, Junchu
Song, Yao-Hua
Li, Yangxin
Ribosome biogenesis in disease: new players and therapeutic targets
title Ribosome biogenesis in disease: new players and therapeutic targets
title_full Ribosome biogenesis in disease: new players and therapeutic targets
title_fullStr Ribosome biogenesis in disease: new players and therapeutic targets
title_full_unstemmed Ribosome biogenesis in disease: new players and therapeutic targets
title_short Ribosome biogenesis in disease: new players and therapeutic targets
title_sort ribosome biogenesis in disease: new players and therapeutic targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826790/
https://www.ncbi.nlm.nih.gov/pubmed/36617563
http://dx.doi.org/10.1038/s41392-022-01285-4
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