Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report

We report a case of intractable Aspergillus otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therape...

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Detalles Bibliográficos
Autores principales: Wee, Liang En, Tan, Mei Gie, Tan, Ai Ling, Tang, Joyce Zhi-en
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826810/
https://www.ncbi.nlm.nih.gov/pubmed/36632528
http://dx.doi.org/10.1016/j.mmcr.2022.12.006
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author Wee, Liang En
Tan, Mei Gie
Tan, Ai Ling
Tang, Joyce Zhi-en
author_facet Wee, Liang En
Tan, Mei Gie
Tan, Ai Ling
Tang, Joyce Zhi-en
author_sort Wee, Liang En
collection PubMed
description We report a case of intractable Aspergillus otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therapeutic drug levels and without treatment interruption; and only resolved after application of topical voriconazole. (max. 75 words)
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spelling pubmed-98268102023-01-10 Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report Wee, Liang En Tan, Mei Gie Tan, Ai Ling Tang, Joyce Zhi-en Med Mycol Case Rep Case Report We report a case of intractable Aspergillus otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therapeutic drug levels and without treatment interruption; and only resolved after application of topical voriconazole. (max. 75 words) Elsevier 2022-12-28 /pmc/articles/PMC9826810/ /pubmed/36632528 http://dx.doi.org/10.1016/j.mmcr.2022.12.006 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wee, Liang En
Tan, Mei Gie
Tan, Ai Ling
Tang, Joyce Zhi-en
Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report
title Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report
title_full Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report
title_fullStr Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report
title_full_unstemmed Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report
title_short Relapsing Aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: A case report
title_sort relapsing aspergillus otomycosis despite prolonged systemic antifungal therapy and resolution after topical voriconazole administration: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826810/
https://www.ncbi.nlm.nih.gov/pubmed/36632528
http://dx.doi.org/10.1016/j.mmcr.2022.12.006
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