Liquid chromatography-mass spectrometry-based protocol to measure drug accumulation in Mycobacterium tuberculosis and its host cell

The extent to which a drug accumulates in Mycobacterium tuberculosis (Mtb) and its host cell can affect treatment efficacy. We describe protocols measuring drug accumulation in Mtb, macrophages, and Mtb-infected macrophages. The method leverages drug extraction from the cellular lysate and drug-leve...

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Detalles Bibliográficos
Autores principales: Ahn, Yong-Mo, Lavin, Richard C., Tan, Shumin, Freundlich, Joel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826881/
https://www.ncbi.nlm.nih.gov/pubmed/36598855
http://dx.doi.org/10.1016/j.xpro.2022.101971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826881/
https://www.ncbi.nlm.nih.gov/pubmed/36598855
http://dx.doi.org/10.1016/j.xpro.2022.101971

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