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Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis

PURPOSE: This systematic review and meta-analysis investigated the sperm retrieval rate (SRR) and pregnancy rate after testicular sperm extraction in men with azoospermia and those with a history of cryptorchidism treated by orchiopexy. MATERIALS AND METHODS: The SRR and clinical pregnancy rate were...

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Autores principales: Kim, Sang Woon, Lee, Jongsoo, Lee, Tae Ho, Kim, Dong Suk, Song, Seung-Hun, Kim, Dae Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Sexual Medicine and Andrology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826915/
https://www.ncbi.nlm.nih.gov/pubmed/35274507
http://dx.doi.org/10.5534/wjmh.210198
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author Kim, Sang Woon
Lee, Jongsoo
Lee, Tae Ho
Kim, Dong Suk
Song, Seung-Hun
Kim, Dae Keun
author_facet Kim, Sang Woon
Lee, Jongsoo
Lee, Tae Ho
Kim, Dong Suk
Song, Seung-Hun
Kim, Dae Keun
author_sort Kim, Sang Woon
collection PubMed
description PURPOSE: This systematic review and meta-analysis investigated the sperm retrieval rate (SRR) and pregnancy rate after testicular sperm extraction in men with azoospermia and those with a history of cryptorchidism treated by orchiopexy. MATERIALS AND METHODS: The SRR and clinical pregnancy rate were investigated. We performed a sub-analysis that included factors such as bilaterality, age, and idiopathic non-obstructive azoospermia (iNOA). The analysis comprised 13 studies from January 1995 to July 2021. The data sources were PubMed/MEDLINE, Embase, and the Cochrane Library included “cryptorchidism”, “orchidopexy”, “azoospermia”, and “testicular sperm extraction”. RESULTS: The overall mean SRR was 63.3% (95% confidence interval [CI], 57.6%–68.6%; I(2)=62.4%), and the overall mean clinical pregnancy rate was 30.1% (95% CI, 22.6%–38.8%; I(2)=69.9%). The meta-analysis comparing the SRR, there was no significant difference between patients with a history of bilateral and unilateral orchiopexy (relative risk [RR]=1.02; 95% CI, 0.89–1.16; p=0.79). Orchiopexy performed under the age of 10 years showed significantly increased SRR compared to the age of over 10 years (RR=1.25; 95% CI, 1.06–1.47; p=0.008). Azoospermic men with a history of cryptorchidism treated by orchiopexy had significantly higher SRR than iNOA (RR=1.90; 95% CI, 1.40–2.58; p<0.0001). CONCLUSIONS: Men with azoospermia and a history of cryptorchidism treated by orchiopexy had significantly higher SRR than those with iNOA after testicular sperm extraction. Furthermore, patients who underwent orchiopexy before the age of ten years had significantly higher SRR than patients operated at an older than the age of ten years.
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spelling pubmed-98269152023-01-19 Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis Kim, Sang Woon Lee, Jongsoo Lee, Tae Ho Kim, Dong Suk Song, Seung-Hun Kim, Dae Keun World J Mens Health Original Article PURPOSE: This systematic review and meta-analysis investigated the sperm retrieval rate (SRR) and pregnancy rate after testicular sperm extraction in men with azoospermia and those with a history of cryptorchidism treated by orchiopexy. MATERIALS AND METHODS: The SRR and clinical pregnancy rate were investigated. We performed a sub-analysis that included factors such as bilaterality, age, and idiopathic non-obstructive azoospermia (iNOA). The analysis comprised 13 studies from January 1995 to July 2021. The data sources were PubMed/MEDLINE, Embase, and the Cochrane Library included “cryptorchidism”, “orchidopexy”, “azoospermia”, and “testicular sperm extraction”. RESULTS: The overall mean SRR was 63.3% (95% confidence interval [CI], 57.6%–68.6%; I(2)=62.4%), and the overall mean clinical pregnancy rate was 30.1% (95% CI, 22.6%–38.8%; I(2)=69.9%). The meta-analysis comparing the SRR, there was no significant difference between patients with a history of bilateral and unilateral orchiopexy (relative risk [RR]=1.02; 95% CI, 0.89–1.16; p=0.79). Orchiopexy performed under the age of 10 years showed significantly increased SRR compared to the age of over 10 years (RR=1.25; 95% CI, 1.06–1.47; p=0.008). Azoospermic men with a history of cryptorchidism treated by orchiopexy had significantly higher SRR than iNOA (RR=1.90; 95% CI, 1.40–2.58; p<0.0001). CONCLUSIONS: Men with azoospermia and a history of cryptorchidism treated by orchiopexy had significantly higher SRR than those with iNOA after testicular sperm extraction. Furthermore, patients who underwent orchiopexy before the age of ten years had significantly higher SRR than patients operated at an older than the age of ten years. Korean Society for Sexual Medicine and Andrology 2023-01 2022-03-10 /pmc/articles/PMC9826915/ /pubmed/35274507 http://dx.doi.org/10.5534/wjmh.210198 Text en Copyright © 2023 Korean Society for Sexual Medicine and Andrology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Sang Woon
Lee, Jongsoo
Lee, Tae Ho
Kim, Dong Suk
Song, Seung-Hun
Kim, Dae Keun
Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis
title Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis
title_full Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis
title_fullStr Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis
title_full_unstemmed Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis
title_short Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis
title_sort azoospermic men with a history of cryptorchidism treated by orchiopexy have favorable outcomes after testicular sperm extraction: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826915/
https://www.ncbi.nlm.nih.gov/pubmed/35274507
http://dx.doi.org/10.5534/wjmh.210198
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