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High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals

PURPOSE: The mean platelet volume (MPV) is regarded as a marker for thrombosis, atherosclerosis, and inflammation in various vascular diseases. However, it still remains unclear whether plasma MPV is associated with cerebral white matter hyperintensities (WMH) and cerebral microvascular pathology in...

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Autores principales: Choi, Jung-Won, Lee, Kee Ook, Jang, Ye-Ji, Kim, Hyun-Kyung, Seo, Taeho, Roh, Yoo Jeong, Choo, Seung-Ook, Oh, Seung-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826963/
https://www.ncbi.nlm.nih.gov/pubmed/36579377
http://dx.doi.org/10.3349/ymj.2022.0368
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author Choi, Jung-Won
Lee, Kee Ook
Jang, Ye-Ji
Kim, Hyun-Kyung
Seo, Taeho
Roh, Yoo Jeong
Choo, Seung-Ook
Oh, Seung-Hun
author_facet Choi, Jung-Won
Lee, Kee Ook
Jang, Ye-Ji
Kim, Hyun-Kyung
Seo, Taeho
Roh, Yoo Jeong
Choo, Seung-Ook
Oh, Seung-Hun
author_sort Choi, Jung-Won
collection PubMed
description PURPOSE: The mean platelet volume (MPV) is regarded as a marker for thrombosis, atherosclerosis, and inflammation in various vascular diseases. However, it still remains unclear whether plasma MPV is associated with cerebral white matter hyperintensities (WMH) and cerebral microvascular pathology in the elderly population. MATERIALS AND METHODS: We examined whether MPV level is associated with the presence of cerebral WMH on brain magnetic resonance imaging from 870 non-stroke outpatient subjects. The subjects were divided into three groups according to the consecutive level of MPV (low T1, middle T2, and high T3 MPV tertile groups). To determine the association of MPV levels with the WMH, logistic regression and receiver operating characteristic curve analyses were conducted. RESULTS: Subjects with higher MPV level were older and more likely to have hypertension, diabetes mellitus, and low renal function. Cerebral WMH were more prevalent in subjects with higher MPV level. After adjusting for confounding factors, moderate to severe cerebral WMH were significantly associated with high MPV tertile level. This association remained significant after adjusting for other cerebral vascular pathologies. T2 [odds ratio (OR): 1.49, 95% confidence interval (CI): 1.03–2.15] and T3 MPV tertile groups (OR: 1.51, 95%CI: 1.04–2.20) had more cerebral WMH lesions compared to T1 MPV tertile group. In addition, the subjects with higher Fazekas scores showed higher MPV level (p=0.020). CONCLUSION: We found that high MPV level is independently associated with cerebral WMH. This result suggests that platelet activation plays a role in the development of cerebral WMH.
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spelling pubmed-98269632023-01-20 High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals Choi, Jung-Won Lee, Kee Ook Jang, Ye-Ji Kim, Hyun-Kyung Seo, Taeho Roh, Yoo Jeong Choo, Seung-Ook Oh, Seung-Hun Yonsei Med J Original Article PURPOSE: The mean platelet volume (MPV) is regarded as a marker for thrombosis, atherosclerosis, and inflammation in various vascular diseases. However, it still remains unclear whether plasma MPV is associated with cerebral white matter hyperintensities (WMH) and cerebral microvascular pathology in the elderly population. MATERIALS AND METHODS: We examined whether MPV level is associated with the presence of cerebral WMH on brain magnetic resonance imaging from 870 non-stroke outpatient subjects. The subjects were divided into three groups according to the consecutive level of MPV (low T1, middle T2, and high T3 MPV tertile groups). To determine the association of MPV levels with the WMH, logistic regression and receiver operating characteristic curve analyses were conducted. RESULTS: Subjects with higher MPV level were older and more likely to have hypertension, diabetes mellitus, and low renal function. Cerebral WMH were more prevalent in subjects with higher MPV level. After adjusting for confounding factors, moderate to severe cerebral WMH were significantly associated with high MPV tertile level. This association remained significant after adjusting for other cerebral vascular pathologies. T2 [odds ratio (OR): 1.49, 95% confidence interval (CI): 1.03–2.15] and T3 MPV tertile groups (OR: 1.51, 95%CI: 1.04–2.20) had more cerebral WMH lesions compared to T1 MPV tertile group. In addition, the subjects with higher Fazekas scores showed higher MPV level (p=0.020). CONCLUSION: We found that high MPV level is independently associated with cerebral WMH. This result suggests that platelet activation plays a role in the development of cerebral WMH. Yonsei University College of Medicine 2023-01 2022-12-08 /pmc/articles/PMC9826963/ /pubmed/36579377 http://dx.doi.org/10.3349/ymj.2022.0368 Text en © Copyright: Yonsei University College of Medicine 2023 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Jung-Won
Lee, Kee Ook
Jang, Ye-Ji
Kim, Hyun-Kyung
Seo, Taeho
Roh, Yoo Jeong
Choo, Seung-Ook
Oh, Seung-Hun
High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals
title High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals
title_full High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals
title_fullStr High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals
title_full_unstemmed High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals
title_short High Mean Platelet Volume Is Associated with Cerebral White Matter Hyperintensities in Non-Stroke Individuals
title_sort high mean platelet volume is associated with cerebral white matter hyperintensities in non-stroke individuals
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826963/
https://www.ncbi.nlm.nih.gov/pubmed/36579377
http://dx.doi.org/10.3349/ymj.2022.0368
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