Nuclear envelope morphology change upon repetitive treatment with modified antisense oligonucleotides targeting Hutchinson-Gilford Progeria Syndrome

We present the influence of treating progeroid fibroblasts with two modified antisense oligonucleotides (ONs) on the nuclear envelope. Two modified ONs were designed to block ribosome binding during translation and spliceosome binding at the cryptic splice site. We analysed the changes in the nuclea...

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Detalles Bibliográficos
Autores principales: Abdelrahman, Asmaa, Nielsen, Mette-Marie Wendelboe, Stage, Mette Halkjær, Arnspang, Eva Christensen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827026/
https://www.ncbi.nlm.nih.gov/pubmed/36632198
http://dx.doi.org/10.1016/j.bbrep.2022.101411

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