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A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing

Non-steroidal anti-inflammatory drugs (NSAIDs) injure the proximal and distal gut by different mechanisms. While many drugs reduce gastrointestinal injury, no drug directly stimulates mucosal wound healing. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, induces epithelial sheet migrati...

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Detalles Bibliográficos
Autores principales:	Wang, Qinggang, Gallardo-Macias, Ricardo, Vomhof-DeKrey, Emilie E., Gupta, Rashmi, Golovko, Svetlana A., Golovko, Mikhail Y., Oncel, Sema, Gurvich, Vadim J., Basson, Marc D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827036/ https://www.ncbi.nlm.nih.gov/pubmed/36632414 http://dx.doi.org/10.1016/j.crphar.2022.100147

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