Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models

Bruton tyrosine kinase (BTK) is an important signaling hub that activates the B-cell receptor (BCR) signaling cascade. BCR activation can contribute to the growth and survival of B-cell lymphoma or leukemia. The inhibition of the BCR signaling pathway is critical for blocking downstream events and t...

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Detalles Bibliográficos
Autores principales: Lim, Ye Seul, Yoo, Sun-Mi, Patil, Vineet, Kim, Han Wool, Kim, Hyun-Hwi, Suh, Beomseon, Park, Ji Youn, Jeong, Na-rae, Park, Chi Hoon, Ryu, Je Ho, Lee, Byung-Hoon, Kim, Pilho, Lee, Song Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827040/
https://www.ncbi.nlm.nih.gov/pubmed/36269842
http://dx.doi.org/10.1182/bloodadvances.2022008121

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