Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

OBJECTIVE: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts gluta...

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Detalles Bibliográficos
Autores principales: Xiang, Zheyi, Bai, Le, Zhou, Jennifer Q., Cevallos, Ricardo R., Sanders, Jonathan R., Liu, Gang, Bernard, Karen, Sanders, Yan Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827063/
https://www.ncbi.nlm.nih.gov/pubmed/36526153
http://dx.doi.org/10.1016/j.molmet.2022.101655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827063/
https://www.ncbi.nlm.nih.gov/pubmed/36526153
http://dx.doi.org/10.1016/j.molmet.2022.101655

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