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Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

OBJECTIVE: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts gluta...

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Detalles Bibliográficos
Autores principales:	Xiang, Zheyi, Bai, Le, Zhou, Jennifer Q., Cevallos, Ricardo R., Sanders, Jonathan R., Liu, Gang, Bernard, Karen, Sanders, Yan Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827063/ https://www.ncbi.nlm.nih.gov/pubmed/36526153 http://dx.doi.org/10.1016/j.molmet.2022.101655

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