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Impact of Genetic Variants in the Nicotine Metabolism Pathway on Nicotine Metabolite Levels in Smokers

BACKGROUND: Nicotine metabolism is a major factor in nicotine dependence, with approximately 70% to 80% of nicotine metabolized to cotinine in Caucasians. Cotinine formation is catalyzed primarily by CYP2A6, which also converts cotinine to trans-3′-hydroxycotinine (3HC). The goal of the present stud...

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Detalles Bibliográficos
Autores principales:	Perez-Paramo, Yadira X., Watson, Christy J.W., Chen, Gang, Thomas, Claire E., Adams-Haduch, Jennifer, Wang, Renwei, Khor, Chiea Chuen, Koh, Woon-Puay, Nelson, Heather H., Yuan, Jian-Min, Lazarus, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827107/ https://www.ncbi.nlm.nih.gov/pubmed/36252563 http://dx.doi.org/10.1158/1055-9965.EPI-22-0868

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