Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy

Intracellular oncoproteins can be inhibited with targeted therapy, but responses are not durable. Immune therapies can be curative, but most oncogene-driven tumors are unresponsive to these agents. Fragments of intracellular oncoproteins can act as neoantigens presented by the major histocompatibili...

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Detalles Bibliográficos
Autores principales: Hattori, Takamitsu, Maso, Lorenzo, Araki, Kiyomi Y., Koide, Akiko, Hayman, James, Akkapeddi, Padma, Bang, Injin, Neel, Benjamin G., Koide, Shohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827112/
https://www.ncbi.nlm.nih.gov/pubmed/36250888
http://dx.doi.org/10.1158/2159-8290.CD-22-1074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827112/
https://www.ncbi.nlm.nih.gov/pubmed/36250888
http://dx.doi.org/10.1158/2159-8290.CD-22-1074

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