Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) tumors, we designed B7-H3–specific chimeric antigen receptor (CAR) T cells, confirmed their preclinical efficacy, and opened BrainChil...

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Detalles Bibliográficos
Autores principales: Vitanza, Nicholas A., Wilson, Ashley L., Huang, Wenjun, Seidel, Kristy, Brown, Christopher, Gustafson, Joshua A., Yokoyama, Jason K., Johnson, Adam J., Baxter, Blake A., Koning, Ryan W., Reid, Aquene N., Meechan, Michael, Biery, Matthew C., Myers, Carrie, Rawlings-Rhea, Stephanie D., Albert, Catherine M., Browd, Samuel R., Hauptman, Jason S., Lee, Amy, Ojemann, Jeffrey G., Berens, Michael E., Dun, Matthew D., Foster, Jessica B., Crotty, Erin E., Leary, Sarah E.S., Cole, Bonnie L., Perez, Francisco A., Wright, Jason N., Orentas, Rimas J., Chour, Tony, Newell, Evan W., Whiteaker, Jeffrey R., Zhao, Lei, Paulovich, Amanda G., Pinto, Navin, Gust, Juliane, Gardner, Rebecca A., Jensen, Michael C., Park, Julie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827115/
https://www.ncbi.nlm.nih.gov/pubmed/36259971
http://dx.doi.org/10.1158/2159-8290.CD-22-0750

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