A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and biochemical approaches, we discovered a conserved m...

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Detalles Bibliográficos
Autores principales: Soto-Feliciano, Yadira M., Sánchez-Rivera, Francisco J., Perner, Florian, Barrows, Douglas W., Kastenhuber, Edward R., Ho, Yu-Jui, Carroll, Thomas, Xiong, Yijun, Anand, Disha, Soshnev, Alexey A., Gates, Leah, Beytagh, Mary Clare, Cheon, David, Gu, Shengqing, Liu, X. Shirley, Krivtsov, Andrei V., Meneses, Maximiliano, de Stanchina, Elisa, Stone, Richard M., Armstrong, Scott A., Lowe, Scott W., Allis, C. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827117/
https://www.ncbi.nlm.nih.gov/pubmed/36264143
http://dx.doi.org/10.1158/2159-8290.CD-22-0416

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