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Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
COVID-19 primarily presents with respiratory involvement. Extrapulmonary manifestations as the sole manifestation also occur although rare. The kidney, being one of the organs with the greatest number of ACE receptors, is usually reported as part of multiorgan involvement. We report an early adolesc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827186/ https://www.ncbi.nlm.nih.gov/pubmed/36604108 http://dx.doi.org/10.1136/bcr-2022-251962 |
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author | Flores, Vincent Albert Galvez Chicano, Sonia Resontoc, Lourdes Paula Aragon, Eric Emmanuel |
author_facet | Flores, Vincent Albert Galvez Chicano, Sonia Resontoc, Lourdes Paula Aragon, Eric Emmanuel |
author_sort | Flores, Vincent Albert Galvez |
collection | PubMed |
description | COVID-19 primarily presents with respiratory involvement. Extrapulmonary manifestations as the sole manifestation also occur although rare. The kidney, being one of the organs with the greatest number of ACE receptors, is usually reported as part of multiorgan involvement. We report an early adolescent boy who presented with nephrotic–nephritic syndrome with severe kidney dysfunction from COVID-19 infection. He had low C3 and undetected antineutrophil cytoplasmic antibodies, antinuclear antibody and antistreptolysin O. Kidney biopsy revealed findings consistent with diffuse proliferative glomerulonephritis with a focal glomerular crescent formation and thin basement nephropathy. Due to the rapidly progressive deterioration of kidney function, he was given pulse methylprednisolone therapy followed by oral prednisone. Complete recovery was documented 12 weeks after the onset of post-infectious glomerulonephritis. The possible pathogenesis of glomerulonephritis in a patient with COVID-19, its differential diagnosis and treatment are discussed. |
format | Online Article Text |
id | pubmed-9827186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-98271862023-01-10 Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection Flores, Vincent Albert Galvez Chicano, Sonia Resontoc, Lourdes Paula Aragon, Eric Emmanuel BMJ Case Rep Case Reports: Unusual association of diseases/symptoms COVID-19 primarily presents with respiratory involvement. Extrapulmonary manifestations as the sole manifestation also occur although rare. The kidney, being one of the organs with the greatest number of ACE receptors, is usually reported as part of multiorgan involvement. We report an early adolescent boy who presented with nephrotic–nephritic syndrome with severe kidney dysfunction from COVID-19 infection. He had low C3 and undetected antineutrophil cytoplasmic antibodies, antinuclear antibody and antistreptolysin O. Kidney biopsy revealed findings consistent with diffuse proliferative glomerulonephritis with a focal glomerular crescent formation and thin basement nephropathy. Due to the rapidly progressive deterioration of kidney function, he was given pulse methylprednisolone therapy followed by oral prednisone. Complete recovery was documented 12 weeks after the onset of post-infectious glomerulonephritis. The possible pathogenesis of glomerulonephritis in a patient with COVID-19, its differential diagnosis and treatment are discussed. BMJ Publishing Group 2023-01-05 /pmc/articles/PMC9827186/ /pubmed/36604108 http://dx.doi.org/10.1136/bcr-2022-251962 Text en © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ. |
spellingShingle | Case Reports: Unusual association of diseases/symptoms Flores, Vincent Albert Galvez Chicano, Sonia Resontoc, Lourdes Paula Aragon, Eric Emmanuel Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection |
title | Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection |
title_full | Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection |
title_fullStr | Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection |
title_full_unstemmed | Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection |
title_short | Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection |
title_sort | diffuse proliferative glomerulonephritis in a patient with covid-19 infection |
topic | Case Reports: Unusual association of diseases/symptoms |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827186/ https://www.ncbi.nlm.nih.gov/pubmed/36604108 http://dx.doi.org/10.1136/bcr-2022-251962 |
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