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Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection

COVID-19 primarily presents with respiratory involvement. Extrapulmonary manifestations as the sole manifestation also occur although rare. The kidney, being one of the organs with the greatest number of ACE receptors, is usually reported as part of multiorgan involvement. We report an early adolesc...

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Autores principales: Flores, Vincent Albert Galvez, Chicano, Sonia, Resontoc, Lourdes Paula, Aragon, Eric Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827186/
https://www.ncbi.nlm.nih.gov/pubmed/36604108
http://dx.doi.org/10.1136/bcr-2022-251962
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author Flores, Vincent Albert Galvez
Chicano, Sonia
Resontoc, Lourdes Paula
Aragon, Eric Emmanuel
author_facet Flores, Vincent Albert Galvez
Chicano, Sonia
Resontoc, Lourdes Paula
Aragon, Eric Emmanuel
author_sort Flores, Vincent Albert Galvez
collection PubMed
description COVID-19 primarily presents with respiratory involvement. Extrapulmonary manifestations as the sole manifestation also occur although rare. The kidney, being one of the organs with the greatest number of ACE receptors, is usually reported as part of multiorgan involvement. We report an early adolescent boy who presented with nephrotic–nephritic syndrome with severe kidney dysfunction from COVID-19 infection. He had low C3 and undetected antineutrophil cytoplasmic antibodies, antinuclear antibody and antistreptolysin O. Kidney biopsy revealed findings consistent with diffuse proliferative glomerulonephritis with a focal glomerular crescent formation and thin basement nephropathy. Due to the rapidly progressive deterioration of kidney function, he was given pulse methylprednisolone therapy followed by oral prednisone. Complete recovery was documented 12 weeks after the onset of post-infectious glomerulonephritis. The possible pathogenesis of glomerulonephritis in a patient with COVID-19, its differential diagnosis and treatment are discussed.
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spelling pubmed-98271862023-01-10 Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection Flores, Vincent Albert Galvez Chicano, Sonia Resontoc, Lourdes Paula Aragon, Eric Emmanuel BMJ Case Rep Case Reports: Unusual association of diseases/symptoms COVID-19 primarily presents with respiratory involvement. Extrapulmonary manifestations as the sole manifestation also occur although rare. The kidney, being one of the organs with the greatest number of ACE receptors, is usually reported as part of multiorgan involvement. We report an early adolescent boy who presented with nephrotic–nephritic syndrome with severe kidney dysfunction from COVID-19 infection. He had low C3 and undetected antineutrophil cytoplasmic antibodies, antinuclear antibody and antistreptolysin O. Kidney biopsy revealed findings consistent with diffuse proliferative glomerulonephritis with a focal glomerular crescent formation and thin basement nephropathy. Due to the rapidly progressive deterioration of kidney function, he was given pulse methylprednisolone therapy followed by oral prednisone. Complete recovery was documented 12 weeks after the onset of post-infectious glomerulonephritis. The possible pathogenesis of glomerulonephritis in a patient with COVID-19, its differential diagnosis and treatment are discussed. BMJ Publishing Group 2023-01-05 /pmc/articles/PMC9827186/ /pubmed/36604108 http://dx.doi.org/10.1136/bcr-2022-251962 Text en © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
spellingShingle Case Reports: Unusual association of diseases/symptoms
Flores, Vincent Albert Galvez
Chicano, Sonia
Resontoc, Lourdes Paula
Aragon, Eric Emmanuel
Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
title Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
title_full Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
title_fullStr Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
title_full_unstemmed Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
title_short Diffuse proliferative glomerulonephritis in a patient with COVID-19 infection
title_sort diffuse proliferative glomerulonephritis in a patient with covid-19 infection
topic Case Reports: Unusual association of diseases/symptoms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827186/
https://www.ncbi.nlm.nih.gov/pubmed/36604108
http://dx.doi.org/10.1136/bcr-2022-251962
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