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Dietary and genetic disruption of hepatic methionine metabolism induce acid sphingomyelinase to promote steatohepatitis

Alcoholic (ASH) and nonalcoholic. (NASH).steatohepatitis are advanced.stages.of.fatty.liver.disease.Methionine adenosyltransferase 1A (MAT1A) plays a key role in hepatic methionine metabolism and germline Mat1a deletion in mice promotes NASH. Acid sphingomyelinase (ASMase) triggers hepatocellular ap...

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Detalles Bibliográficos
Autores principales:	Alarcón-Vila, Cristina, Insausti-Urkia, Naroa, Torres, Sandra, Segalés-Rovira, Paula, Conde de la Rosa, Laura, Nuñez, Susana, Fucho, Raquel, Fernández-Checa, Jose C., García-Ruiz, Carmen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827379/ https://www.ncbi.nlm.nih.gov/pubmed/36610223 http://dx.doi.org/10.1016/j.redox.2022.102596

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