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Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient

Patient: Male, 33-year-old Final Diagnosis: Cutaneous adverse drug reaction • drug induced immune thrombocytopenia Symptoms: Pruritic skin lesion in the entire body since seven days prior to admission and skin lesion with red patches in the trunk Medication: — Clinical Procedure: — Specialty: Infect...

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Autores principales: Lugito, Nata Pratama Hardjo, Kurniawan, Andree, Jayadi, Nana Novia, Kristiani, Erna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827413/
https://www.ncbi.nlm.nih.gov/pubmed/36600572
http://dx.doi.org/10.12659/AJCR.938358
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author Lugito, Nata Pratama Hardjo
Kurniawan, Andree
Jayadi, Nana Novia
Kristiani, Erna
author_facet Lugito, Nata Pratama Hardjo
Kurniawan, Andree
Jayadi, Nana Novia
Kristiani, Erna
author_sort Lugito, Nata Pratama Hardjo
collection PubMed
description Patient: Male, 33-year-old Final Diagnosis: Cutaneous adverse drug reaction • drug induced immune thrombocytopenia Symptoms: Pruritic skin lesion in the entire body since seven days prior to admission and skin lesion with red patches in the trunk Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Unknown etiology BACKGROUND: Many drugs have been reported to cause immune-mediated adverse drug reactions (IM-ADRs) in human immunodeficiency virus (HIV) patients; the most common is cutaneous adverse drug reaction (CADR). Immune thrombocytopenia purpura (ITP) is frequent in HIV patients, and it can be caused HIV, opportunistic infections, or drugs. Although drugs can cause immune thrombocytopenia, termed drug-induced immune thrombocytopenia (DIIT), there has been no study on DIIT in HIV patients. CASE REPORT: A 33-year-old male patient was admitted to our hospital with pruritic skin lesion over the entire body, which started 7 days before. He was diagnosed with HIV infection, brain toxoplasmosis, and pulmonary tuberculosis 2 weeks before admission, and was given trimethoprim sulphamethoxazole, isoniazid, rifampicin, pyrazin-amide, and ethambutol. Clindamycin was added 10 days before admission. Skin examination revealed generalized erythematous macules with palpable petechiae and purpura. The platelet count was 141 000/µL when he was diagnosed with HIV, and it was 2000/µL at the time of admission. Clindamycin was discontinued and he was given steroids and platelet transfusion. The skin lesions improved along with an increased platelet count. He was discharged on the 10(th) day of admission, with platelet count of 42 000/µL. When he returned to the outpatient clinic on the 15(th) day, his platelet was 54 000/µL. The skin lesions had resolved completely and become hyperpigmented, and no purpura or petechiae were seen. CONCLUSIONS: We present a case of an HIV patient with IM-ADR in the form of DIIT in conjunction with CADR that might have been caused by clindamycin.
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spelling pubmed-98274132023-01-26 Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient Lugito, Nata Pratama Hardjo Kurniawan, Andree Jayadi, Nana Novia Kristiani, Erna Am J Case Rep Articles Patient: Male, 33-year-old Final Diagnosis: Cutaneous adverse drug reaction • drug induced immune thrombocytopenia Symptoms: Pruritic skin lesion in the entire body since seven days prior to admission and skin lesion with red patches in the trunk Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Unknown etiology BACKGROUND: Many drugs have been reported to cause immune-mediated adverse drug reactions (IM-ADRs) in human immunodeficiency virus (HIV) patients; the most common is cutaneous adverse drug reaction (CADR). Immune thrombocytopenia purpura (ITP) is frequent in HIV patients, and it can be caused HIV, opportunistic infections, or drugs. Although drugs can cause immune thrombocytopenia, termed drug-induced immune thrombocytopenia (DIIT), there has been no study on DIIT in HIV patients. CASE REPORT: A 33-year-old male patient was admitted to our hospital with pruritic skin lesion over the entire body, which started 7 days before. He was diagnosed with HIV infection, brain toxoplasmosis, and pulmonary tuberculosis 2 weeks before admission, and was given trimethoprim sulphamethoxazole, isoniazid, rifampicin, pyrazin-amide, and ethambutol. Clindamycin was added 10 days before admission. Skin examination revealed generalized erythematous macules with palpable petechiae and purpura. The platelet count was 141 000/µL when he was diagnosed with HIV, and it was 2000/µL at the time of admission. Clindamycin was discontinued and he was given steroids and platelet transfusion. The skin lesions improved along with an increased platelet count. He was discharged on the 10(th) day of admission, with platelet count of 42 000/µL. When he returned to the outpatient clinic on the 15(th) day, his platelet was 54 000/µL. The skin lesions had resolved completely and become hyperpigmented, and no purpura or petechiae were seen. CONCLUSIONS: We present a case of an HIV patient with IM-ADR in the form of DIIT in conjunction with CADR that might have been caused by clindamycin. International Scientific Literature, Inc. 2023-01-05 /pmc/articles/PMC9827413/ /pubmed/36600572 http://dx.doi.org/10.12659/AJCR.938358 Text en © Am J Case Rep, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Lugito, Nata Pratama Hardjo
Kurniawan, Andree
Jayadi, Nana Novia
Kristiani, Erna
Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
title Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
title_full Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
title_fullStr Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
title_full_unstemmed Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
title_short Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
title_sort immune-mediated adverse drug reactions (im-ards) in the form of drug-induced immune thrombocytopenia and cutaneous adverse drug reactions (card) due to clindamycin in an human immunodeficieny virus (hiv) patient
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827413/
https://www.ncbi.nlm.nih.gov/pubmed/36600572
http://dx.doi.org/10.12659/AJCR.938358
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