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Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient
Patient: Male, 33-year-old Final Diagnosis: Cutaneous adverse drug reaction • drug induced immune thrombocytopenia Symptoms: Pruritic skin lesion in the entire body since seven days prior to admission and skin lesion with red patches in the trunk Medication: — Clinical Procedure: — Specialty: Infect...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827413/ https://www.ncbi.nlm.nih.gov/pubmed/36600572 http://dx.doi.org/10.12659/AJCR.938358 |
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author | Lugito, Nata Pratama Hardjo Kurniawan, Andree Jayadi, Nana Novia Kristiani, Erna |
author_facet | Lugito, Nata Pratama Hardjo Kurniawan, Andree Jayadi, Nana Novia Kristiani, Erna |
author_sort | Lugito, Nata Pratama Hardjo |
collection | PubMed |
description | Patient: Male, 33-year-old Final Diagnosis: Cutaneous adverse drug reaction • drug induced immune thrombocytopenia Symptoms: Pruritic skin lesion in the entire body since seven days prior to admission and skin lesion with red patches in the trunk Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Unknown etiology BACKGROUND: Many drugs have been reported to cause immune-mediated adverse drug reactions (IM-ADRs) in human immunodeficiency virus (HIV) patients; the most common is cutaneous adverse drug reaction (CADR). Immune thrombocytopenia purpura (ITP) is frequent in HIV patients, and it can be caused HIV, opportunistic infections, or drugs. Although drugs can cause immune thrombocytopenia, termed drug-induced immune thrombocytopenia (DIIT), there has been no study on DIIT in HIV patients. CASE REPORT: A 33-year-old male patient was admitted to our hospital with pruritic skin lesion over the entire body, which started 7 days before. He was diagnosed with HIV infection, brain toxoplasmosis, and pulmonary tuberculosis 2 weeks before admission, and was given trimethoprim sulphamethoxazole, isoniazid, rifampicin, pyrazin-amide, and ethambutol. Clindamycin was added 10 days before admission. Skin examination revealed generalized erythematous macules with palpable petechiae and purpura. The platelet count was 141 000/µL when he was diagnosed with HIV, and it was 2000/µL at the time of admission. Clindamycin was discontinued and he was given steroids and platelet transfusion. The skin lesions improved along with an increased platelet count. He was discharged on the 10(th) day of admission, with platelet count of 42 000/µL. When he returned to the outpatient clinic on the 15(th) day, his platelet was 54 000/µL. The skin lesions had resolved completely and become hyperpigmented, and no purpura or petechiae were seen. CONCLUSIONS: We present a case of an HIV patient with IM-ADR in the form of DIIT in conjunction with CADR that might have been caused by clindamycin. |
format | Online Article Text |
id | pubmed-9827413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98274132023-01-26 Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient Lugito, Nata Pratama Hardjo Kurniawan, Andree Jayadi, Nana Novia Kristiani, Erna Am J Case Rep Articles Patient: Male, 33-year-old Final Diagnosis: Cutaneous adverse drug reaction • drug induced immune thrombocytopenia Symptoms: Pruritic skin lesion in the entire body since seven days prior to admission and skin lesion with red patches in the trunk Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Unknown etiology BACKGROUND: Many drugs have been reported to cause immune-mediated adverse drug reactions (IM-ADRs) in human immunodeficiency virus (HIV) patients; the most common is cutaneous adverse drug reaction (CADR). Immune thrombocytopenia purpura (ITP) is frequent in HIV patients, and it can be caused HIV, opportunistic infections, or drugs. Although drugs can cause immune thrombocytopenia, termed drug-induced immune thrombocytopenia (DIIT), there has been no study on DIIT in HIV patients. CASE REPORT: A 33-year-old male patient was admitted to our hospital with pruritic skin lesion over the entire body, which started 7 days before. He was diagnosed with HIV infection, brain toxoplasmosis, and pulmonary tuberculosis 2 weeks before admission, and was given trimethoprim sulphamethoxazole, isoniazid, rifampicin, pyrazin-amide, and ethambutol. Clindamycin was added 10 days before admission. Skin examination revealed generalized erythematous macules with palpable petechiae and purpura. The platelet count was 141 000/µL when he was diagnosed with HIV, and it was 2000/µL at the time of admission. Clindamycin was discontinued and he was given steroids and platelet transfusion. The skin lesions improved along with an increased platelet count. He was discharged on the 10(th) day of admission, with platelet count of 42 000/µL. When he returned to the outpatient clinic on the 15(th) day, his platelet was 54 000/µL. The skin lesions had resolved completely and become hyperpigmented, and no purpura or petechiae were seen. CONCLUSIONS: We present a case of an HIV patient with IM-ADR in the form of DIIT in conjunction with CADR that might have been caused by clindamycin. International Scientific Literature, Inc. 2023-01-05 /pmc/articles/PMC9827413/ /pubmed/36600572 http://dx.doi.org/10.12659/AJCR.938358 Text en © Am J Case Rep, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Lugito, Nata Pratama Hardjo Kurniawan, Andree Jayadi, Nana Novia Kristiani, Erna Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient |
title | Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient |
title_full | Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient |
title_fullStr | Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient |
title_full_unstemmed | Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient |
title_short | Immune-Mediated Adverse Drug Reactions (IM-ARDs) in the Form of Drug-Induced Immune Thrombocytopenia and Cutaneous Adverse Drug Reactions (CARD) Due to Clindamycin in an Human Immunodeficieny Virus (HIV) Patient |
title_sort | immune-mediated adverse drug reactions (im-ards) in the form of drug-induced immune thrombocytopenia and cutaneous adverse drug reactions (card) due to clindamycin in an human immunodeficieny virus (hiv) patient |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827413/ https://www.ncbi.nlm.nih.gov/pubmed/36600572 http://dx.doi.org/10.12659/AJCR.938358 |
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