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Carcinomatous meningitis from ovarian serous carcinoma: A case report

Multifocal dissemination of cancer cells from the primary tumor sites to the subarachnoid, pia mater and cerebrospinal fluid (CSF) of the brain and spinal cord causes carcinomatous meningitis (CM). CM is rarely observed in patients with gynecological cancer. The present study described a 59-year-old...

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Autores principales: Uchikura, Eijiro, Fukuda, Takeshi, Imai, Kenji, Yamauchi, Makoto, Kasai, Mari, Ichimura, Tomoyuki, Yasui, Tomoyo, Kuwae, Yuko, Sumi, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827457/
https://www.ncbi.nlm.nih.gov/pubmed/36644158
http://dx.doi.org/10.3892/ol.2022.13652
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author Uchikura, Eijiro
Fukuda, Takeshi
Imai, Kenji
Yamauchi, Makoto
Kasai, Mari
Ichimura, Tomoyuki
Yasui, Tomoyo
Kuwae, Yuko
Sumi, Toshiyuki
author_facet Uchikura, Eijiro
Fukuda, Takeshi
Imai, Kenji
Yamauchi, Makoto
Kasai, Mari
Ichimura, Tomoyuki
Yasui, Tomoyo
Kuwae, Yuko
Sumi, Toshiyuki
author_sort Uchikura, Eijiro
collection PubMed
description Multifocal dissemination of cancer cells from the primary tumor sites to the subarachnoid, pia mater and cerebrospinal fluid (CSF) of the brain and spinal cord causes carcinomatous meningitis (CM). CM is rarely observed in patients with gynecological cancer. The present study described a 59-year-old woman who was diagnosed with CM as a recurrence of stage IIIC ovarian cancer, after presenting with headache and decreased level of consciousness. During adjuvant therapy following surgical debulking, she developed nausea and vomiting. The post-contrast fluid-attenuated inversion-recovery magnetic resonance imaging showed leptomeningeal enhancement on all sulci, particularly around the falx cerebri and cerebellar hemisphere. CM was suspected and CSF cytology revealed adenocarcinoma cells, thus confirming the diagnosis. Overall, although CM is rare, clinicians should be aware of this complication when patients with malignancies experience neurological symptoms, including headache, nausea and vomiting. Knowledge of this clinical entity should assist clinicians in ascertaining accurate diagnoses.
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spelling pubmed-98274572023-01-13 Carcinomatous meningitis from ovarian serous carcinoma: A case report Uchikura, Eijiro Fukuda, Takeshi Imai, Kenji Yamauchi, Makoto Kasai, Mari Ichimura, Tomoyuki Yasui, Tomoyo Kuwae, Yuko Sumi, Toshiyuki Oncol Lett Articles Multifocal dissemination of cancer cells from the primary tumor sites to the subarachnoid, pia mater and cerebrospinal fluid (CSF) of the brain and spinal cord causes carcinomatous meningitis (CM). CM is rarely observed in patients with gynecological cancer. The present study described a 59-year-old woman who was diagnosed with CM as a recurrence of stage IIIC ovarian cancer, after presenting with headache and decreased level of consciousness. During adjuvant therapy following surgical debulking, she developed nausea and vomiting. The post-contrast fluid-attenuated inversion-recovery magnetic resonance imaging showed leptomeningeal enhancement on all sulci, particularly around the falx cerebri and cerebellar hemisphere. CM was suspected and CSF cytology revealed adenocarcinoma cells, thus confirming the diagnosis. Overall, although CM is rare, clinicians should be aware of this complication when patients with malignancies experience neurological symptoms, including headache, nausea and vomiting. Knowledge of this clinical entity should assist clinicians in ascertaining accurate diagnoses. D.A. Spandidos 2022-12-23 /pmc/articles/PMC9827457/ /pubmed/36644158 http://dx.doi.org/10.3892/ol.2022.13652 Text en Copyright: © Uchikura et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Uchikura, Eijiro
Fukuda, Takeshi
Imai, Kenji
Yamauchi, Makoto
Kasai, Mari
Ichimura, Tomoyuki
Yasui, Tomoyo
Kuwae, Yuko
Sumi, Toshiyuki
Carcinomatous meningitis from ovarian serous carcinoma: A case report
title Carcinomatous meningitis from ovarian serous carcinoma: A case report
title_full Carcinomatous meningitis from ovarian serous carcinoma: A case report
title_fullStr Carcinomatous meningitis from ovarian serous carcinoma: A case report
title_full_unstemmed Carcinomatous meningitis from ovarian serous carcinoma: A case report
title_short Carcinomatous meningitis from ovarian serous carcinoma: A case report
title_sort carcinomatous meningitis from ovarian serous carcinoma: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827457/
https://www.ncbi.nlm.nih.gov/pubmed/36644158
http://dx.doi.org/10.3892/ol.2022.13652
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