When aging gets on the way of disposal: Senescent cell suppression of efferocytosis

Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of macrophages to engulf them and additionally prevent macrop...

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Detalles Bibliográficos
Autores principales: Rothlin, Carla V., Ghosh, Sourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827511/
https://www.ncbi.nlm.nih.gov/pubmed/36602762
http://dx.doi.org/10.1083/jcb.202212023
Descripción
Sumario:Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of macrophages to engulf them and additionally prevent macrophages from removing neighboring corpses, revealing a new mechanism by which senescence may contribute to triggering inflammation.

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