When aging gets on the way of disposal: Senescent cell suppression of efferocytosis

Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of macrophages to engulf them and additionally prevent macrop...

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Detalles Bibliográficos
Autores principales: Rothlin, Carla V., Ghosh, Sourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827511/
https://www.ncbi.nlm.nih.gov/pubmed/36602762
http://dx.doi.org/10.1083/jcb.202212023
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author Rothlin, Carla V.
Ghosh, Sourav
author_facet Rothlin, Carla V.
Ghosh, Sourav
author_sort Rothlin, Carla V.
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description Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of macrophages to engulf them and additionally prevent macrophages from removing neighboring corpses, revealing a new mechanism by which senescence may contribute to triggering inflammation.
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spelling pubmed-98275112023-07-05 When aging gets on the way of disposal: Senescent cell suppression of efferocytosis Rothlin, Carla V. Ghosh, Sourav J Cell Biol Spotlight Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of macrophages to engulf them and additionally prevent macrophages from removing neighboring corpses, revealing a new mechanism by which senescence may contribute to triggering inflammation. Rockefeller University Press 2023-01-05 /pmc/articles/PMC9827511/ /pubmed/36602762 http://dx.doi.org/10.1083/jcb.202212023 Text en © 2023 Rothlin and Ghosh https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Rothlin, Carla V.
Ghosh, Sourav
When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
title When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
title_full When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
title_fullStr When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
title_full_unstemmed When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
title_short When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
title_sort when aging gets on the way of disposal: senescent cell suppression of efferocytosis
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827511/
https://www.ncbi.nlm.nih.gov/pubmed/36602762
http://dx.doi.org/10.1083/jcb.202212023
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