Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy

Plastin 3 (PLS3) is an F-actin-bundling protein that has gained attention as a modifier of spinal muscular atrophy (SMA) pathology. SMA is a lethal pediatric neuromuscular disease caused by loss of or mutations in the Survival Motor Neuron 1 (SMN1) gene. Pathophysiological hallmarks are cellular mat...

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Detalles Bibliográficos
Autores principales: Hennlein, Luisa, Ghanawi, Hanaa, Gerstner, Florian, Palominos García, Eduardo, Yildirim, Ezgi, Saal-Bauernschubert, Lena, Moradi, Mehri, Deng, Chunchu, Klein, Teresa, Appenzeller, Silke, Sauer, Markus, Briese, Michael, Simon, Christian, Sendtner, Michael, Jablonka, Sibylle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827530/
https://www.ncbi.nlm.nih.gov/pubmed/36607273
http://dx.doi.org/10.1083/jcb.202204113

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