Cargando…
Chx10+V2a interneurons in spinal motor regulation and spinal cord injury
Chx10-expressing V2a (Chx10+V2a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2a interneurons in the regulation of locomotor initiation, maintenance, alternation, speed, and rhythmicity. T...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827767/ https://www.ncbi.nlm.nih.gov/pubmed/36254971 http://dx.doi.org/10.4103/1673-5374.355746 |
_version_ | 1784867115311824896 |
---|---|
author | Li, Wen-Yuan Deng, Ling-Xiao Zhai, Feng-Guo Wang, Xiao-Yu Li, Zhi-Gang Wang, Ying |
author_facet | Li, Wen-Yuan Deng, Ling-Xiao Zhai, Feng-Guo Wang, Xiao-Yu Li, Zhi-Gang Wang, Ying |
author_sort | Li, Wen-Yuan |
collection | PubMed |
description | Chx10-expressing V2a (Chx10+V2a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2a interneurons in the regulation of locomotor initiation, maintenance, alternation, speed, and rhythmicity. The role of Chx10+V2a interneurons in locomotion and autonomic nervous system regulation is thought to be robust, but their precise role in spinal motor regulation and spinal cord injury have not been fully explored. The present paper reviews the origin, characteristics, and functional roles of Chx10+V2a interneurons with an emphasis on their involvement in the pathogenesis of spinal cord injury. The diverse functional properties of these cells have only been substantiated by and are due in large part to their integration in a variety of diverse spinal circuits. Chx10+V2a interneurons play an integral role in conferring locomotion, which integrates various corticospinal, mechanosensory, and interneuron pathways. Moreover, accumulating evidence suggests that Chx10+V2a interneurons also play an important role in rhythmic patterning maintenance, left-right alternation of central pattern generation, and locomotor pattern generation in higher order mammals, likely conferring complex locomotion. Consequently, the latest research has focused on postinjury transplantation and noninvasive stimulation of Chx10+V2a interneurons as a therapeutic strategy, particularly in spinal cord injury. Finally, we review the latest preclinical study advances in laboratory derivation and stimulation/transplantation of these cells as a strategy for the treatment of spinal cord injury. The evidence supports that the Chx10+V2a interneurons act as a new therapeutic target for spinal cord injury. Future optimization strategies should focus on the viability, maturity, and functional integration of Chx10+V2a interneurons transplanted in spinal cord injury foci. |
format | Online Article Text |
id | pubmed-9827767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-98277672023-01-10 Chx10+V2a interneurons in spinal motor regulation and spinal cord injury Li, Wen-Yuan Deng, Ling-Xiao Zhai, Feng-Guo Wang, Xiao-Yu Li, Zhi-Gang Wang, Ying Neural Regen Res Review Chx10-expressing V2a (Chx10+V2a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2a interneurons in the regulation of locomotor initiation, maintenance, alternation, speed, and rhythmicity. The role of Chx10+V2a interneurons in locomotion and autonomic nervous system regulation is thought to be robust, but their precise role in spinal motor regulation and spinal cord injury have not been fully explored. The present paper reviews the origin, characteristics, and functional roles of Chx10+V2a interneurons with an emphasis on their involvement in the pathogenesis of spinal cord injury. The diverse functional properties of these cells have only been substantiated by and are due in large part to their integration in a variety of diverse spinal circuits. Chx10+V2a interneurons play an integral role in conferring locomotion, which integrates various corticospinal, mechanosensory, and interneuron pathways. Moreover, accumulating evidence suggests that Chx10+V2a interneurons also play an important role in rhythmic patterning maintenance, left-right alternation of central pattern generation, and locomotor pattern generation in higher order mammals, likely conferring complex locomotion. Consequently, the latest research has focused on postinjury transplantation and noninvasive stimulation of Chx10+V2a interneurons as a therapeutic strategy, particularly in spinal cord injury. Finally, we review the latest preclinical study advances in laboratory derivation and stimulation/transplantation of these cells as a strategy for the treatment of spinal cord injury. The evidence supports that the Chx10+V2a interneurons act as a new therapeutic target for spinal cord injury. Future optimization strategies should focus on the viability, maturity, and functional integration of Chx10+V2a interneurons transplanted in spinal cord injury foci. Wolters Kluwer - Medknow 2022-10-10 /pmc/articles/PMC9827767/ /pubmed/36254971 http://dx.doi.org/10.4103/1673-5374.355746 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Li, Wen-Yuan Deng, Ling-Xiao Zhai, Feng-Guo Wang, Xiao-Yu Li, Zhi-Gang Wang, Ying Chx10+V2a interneurons in spinal motor regulation and spinal cord injury |
title | Chx10+V2a interneurons in spinal motor regulation and spinal cord injury |
title_full | Chx10+V2a interneurons in spinal motor regulation and spinal cord injury |
title_fullStr | Chx10+V2a interneurons in spinal motor regulation and spinal cord injury |
title_full_unstemmed | Chx10+V2a interneurons in spinal motor regulation and spinal cord injury |
title_short | Chx10+V2a interneurons in spinal motor regulation and spinal cord injury |
title_sort | chx10+v2a interneurons in spinal motor regulation and spinal cord injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827767/ https://www.ncbi.nlm.nih.gov/pubmed/36254971 http://dx.doi.org/10.4103/1673-5374.355746 |
work_keys_str_mv | AT liwenyuan chx10v2ainterneuronsinspinalmotorregulationandspinalcordinjury AT denglingxiao chx10v2ainterneuronsinspinalmotorregulationandspinalcordinjury AT zhaifengguo chx10v2ainterneuronsinspinalmotorregulationandspinalcordinjury AT wangxiaoyu chx10v2ainterneuronsinspinalmotorregulationandspinalcordinjury AT lizhigang chx10v2ainterneuronsinspinalmotorregulationandspinalcordinjury AT wangying chx10v2ainterneuronsinspinalmotorregulationandspinalcordinjury |