SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19

Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptiv...

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Detalles Bibliográficos
Autores principales: Wang, Yating, Abolhassani, Hassan, Hammarström, Lennart, Pan-Hammarström, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827799/
https://www.ncbi.nlm.nih.gov/pubmed/35713311
http://dx.doi.org/10.3724/abbs.2022071
Descripción
Sumario:Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.

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