SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19

Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptiv...

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Autores principales: Wang, Yating, Abolhassani, Hassan, Hammarström, Lennart, Pan-Hammarström, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827799/
https://www.ncbi.nlm.nih.gov/pubmed/35713311
http://dx.doi.org/10.3724/abbs.2022071
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author Wang, Yating
Abolhassani, Hassan
Hammarström, Lennart
Pan-Hammarström, Qiang
author_facet Wang, Yating
Abolhassani, Hassan
Hammarström, Lennart
Pan-Hammarström, Qiang
author_sort Wang, Yating
collection PubMed
description Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.
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spelling pubmed-98277992023-02-10 SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19 Wang, Yating Abolhassani, Hassan Hammarström, Lennart Pan-Hammarström, Qiang Acta Biochim Biophys Sin (Shanghai) Research Article Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population. Oxford University Press 2022-06-15 /pmc/articles/PMC9827799/ /pubmed/35713311 http://dx.doi.org/10.3724/abbs.2022071 Text en © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Wang, Yating
Abolhassani, Hassan
Hammarström, Lennart
Pan-Hammarström, Qiang
SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19
title SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19
title_full SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19
title_fullStr SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19
title_full_unstemmed SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19
title_short SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects: DNA repair deficiency and COVID19
title_sort sars-cov-2 infection in patients with inborn errors of immunity due to dna repair defects: dna repair deficiency and covid19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827799/
https://www.ncbi.nlm.nih.gov/pubmed/35713311
http://dx.doi.org/10.3724/abbs.2022071
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