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Increased Phospho‐AKT in Blood Cells from LRRK2 G2019S Mutation Carriers
The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)‐Ser‐935‐LRRK2 and P‐Ser‐473‐AKT levels in peripheral blood cells from patients with G2019S LRRK2‐associate...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827833/ https://www.ncbi.nlm.nih.gov/pubmed/35929078 http://dx.doi.org/10.1002/ana.26469 |
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| author | Garrido, Alicia Pérez‐Sisqués, Leticia Simonet, Cristina Campoy‐Campos, Genís Solana‐Balaguer, Júlia Martín‐Flores, Núria Fernández, Manel Soto, Marta Obiang, Donina Cámara, Ana Valldeoriola, Francesc Muñoz, Esteban Compta, Yaroslau Pérez‐Navarro, Esther Alberch, Jordi Tolosa, Eduardo Martí, María‐José Ezquerra, Mario Malagelada, Cristina Fernández‐Santiago, Rubén |
| author_facet | Garrido, Alicia Pérez‐Sisqués, Leticia Simonet, Cristina Campoy‐Campos, Genís Solana‐Balaguer, Júlia Martín‐Flores, Núria Fernández, Manel Soto, Marta Obiang, Donina Cámara, Ana Valldeoriola, Francesc Muñoz, Esteban Compta, Yaroslau Pérez‐Navarro, Esther Alberch, Jordi Tolosa, Eduardo Martí, María‐José Ezquerra, Mario Malagelada, Cristina Fernández‐Santiago, Rubén |
| author_sort | Garrido, Alicia |
| collection | PubMed |
| description | The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)‐Ser‐935‐LRRK2 and P‐Ser‐473‐AKT levels in peripheral blood cells from patients with G2019S LRRK2‐associated PD (L2PD, n = 31), G2019S LRRK2 non‐manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls (n = 40, total n = 122). We found no differences at P‐Ser‐935‐LRRK2 between groups but detected a specific increase of P‐Ser‐473‐AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P‐Ser‐473‐AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood cells. ANN NEUROL 2022;92:888–894 |
| format | Online Article Text |
| id | pubmed-9827833 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley & Sons, Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98278332023-01-10 Increased Phospho‐AKT in Blood Cells from LRRK2 G2019S Mutation Carriers Garrido, Alicia Pérez‐Sisqués, Leticia Simonet, Cristina Campoy‐Campos, Genís Solana‐Balaguer, Júlia Martín‐Flores, Núria Fernández, Manel Soto, Marta Obiang, Donina Cámara, Ana Valldeoriola, Francesc Muñoz, Esteban Compta, Yaroslau Pérez‐Navarro, Esther Alberch, Jordi Tolosa, Eduardo Martí, María‐José Ezquerra, Mario Malagelada, Cristina Fernández‐Santiago, Rubén Ann Neurol Brief Communications The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)‐Ser‐935‐LRRK2 and P‐Ser‐473‐AKT levels in peripheral blood cells from patients with G2019S LRRK2‐associated PD (L2PD, n = 31), G2019S LRRK2 non‐manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls (n = 40, total n = 122). We found no differences at P‐Ser‐935‐LRRK2 between groups but detected a specific increase of P‐Ser‐473‐AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P‐Ser‐473‐AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood cells. ANN NEUROL 2022;92:888–894 John Wiley & Sons, Inc. 2022-09-26 2022-11 /pmc/articles/PMC9827833/ /pubmed/35929078 http://dx.doi.org/10.1002/ana.26469 Text en © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Brief Communications Garrido, Alicia Pérez‐Sisqués, Leticia Simonet, Cristina Campoy‐Campos, Genís Solana‐Balaguer, Júlia Martín‐Flores, Núria Fernández, Manel Soto, Marta Obiang, Donina Cámara, Ana Valldeoriola, Francesc Muñoz, Esteban Compta, Yaroslau Pérez‐Navarro, Esther Alberch, Jordi Tolosa, Eduardo Martí, María‐José Ezquerra, Mario Malagelada, Cristina Fernández‐Santiago, Rubén Increased Phospho‐AKT in Blood Cells from LRRK2 G2019S Mutation Carriers |
| title | Increased Phospho‐AKT in Blood Cells from
LRRK2 G2019S Mutation Carriers |
| title_full | Increased Phospho‐AKT in Blood Cells from
LRRK2 G2019S Mutation Carriers |
| title_fullStr | Increased Phospho‐AKT in Blood Cells from
LRRK2 G2019S Mutation Carriers |
| title_full_unstemmed | Increased Phospho‐AKT in Blood Cells from
LRRK2 G2019S Mutation Carriers |
| title_short | Increased Phospho‐AKT in Blood Cells from
LRRK2 G2019S Mutation Carriers |
| title_sort | increased phospho‐akt in blood cells from
lrrk2 g2019s mutation carriers |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827833/ https://www.ncbi.nlm.nih.gov/pubmed/35929078 http://dx.doi.org/10.1002/ana.26469 |
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