In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery

Target‐directed dynamic combinatorial chemistry has emerged as a useful tool for hit identification, but has not been widely used, in part due to challenges associated with analyses involving complex mixtures. We describe an operationally simple alternative: in situ inhibitor synthesis and screening...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhihong, Wu, Yue, Zhen, Shuai, Su, Kaijun, Zhang, Linjian, Yang, Fulai, McDonough, Michael A., Schofield, Christopher J., Zhang, Xiaojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827864/
https://www.ncbi.nlm.nih.gov/pubmed/36112310
http://dx.doi.org/10.1002/anie.202211510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827864/
https://www.ncbi.nlm.nih.gov/pubmed/36112310
http://dx.doi.org/10.1002/anie.202211510

Ejemplares similares