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Signals triggering prophage induction in the gut microbiota
Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying pro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827884/ https://www.ncbi.nlm.nih.gov/pubmed/36164818 http://dx.doi.org/10.1111/mmi.14983 |
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author | Henrot, Caroline Petit, Marie‐Agnès |
author_facet | Henrot, Caroline Petit, Marie‐Agnès |
author_sort | Henrot, Caroline |
collection | PubMed |
description | Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying prophages. In addition, prophage induction rates are higher in the gut than in vitro. However, studies on the signals leading to prophage induction have essentially focused on genotoxic agents with poor relevance for this environment. In this review, we sum up recent findings about signals able to trigger prophage induction in the gut. Three categories of signals are at play: those originating from interactions between intestinal microbes, those from the human or animal host physiology and those from external intakes. These recent results highlight the diversity of factors influencing prophage induction in the gut, and start to unveil ways by which microbiota composition may be modulated. |
format | Online Article Text |
id | pubmed-9827884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98278842023-01-10 Signals triggering prophage induction in the gut microbiota Henrot, Caroline Petit, Marie‐Agnès Mol Microbiol Micro Reviews Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying prophages. In addition, prophage induction rates are higher in the gut than in vitro. However, studies on the signals leading to prophage induction have essentially focused on genotoxic agents with poor relevance for this environment. In this review, we sum up recent findings about signals able to trigger prophage induction in the gut. Three categories of signals are at play: those originating from interactions between intestinal microbes, those from the human or animal host physiology and those from external intakes. These recent results highlight the diversity of factors influencing prophage induction in the gut, and start to unveil ways by which microbiota composition may be modulated. John Wiley and Sons Inc. 2022-10-18 2022-11 /pmc/articles/PMC9827884/ /pubmed/36164818 http://dx.doi.org/10.1111/mmi.14983 Text en © 2022 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Micro Reviews Henrot, Caroline Petit, Marie‐Agnès Signals triggering prophage induction in the gut microbiota |
title | Signals triggering prophage induction in the gut microbiota |
title_full | Signals triggering prophage induction in the gut microbiota |
title_fullStr | Signals triggering prophage induction in the gut microbiota |
title_full_unstemmed | Signals triggering prophage induction in the gut microbiota |
title_short | Signals triggering prophage induction in the gut microbiota |
title_sort | signals triggering prophage induction in the gut microbiota |
topic | Micro Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827884/ https://www.ncbi.nlm.nih.gov/pubmed/36164818 http://dx.doi.org/10.1111/mmi.14983 |
work_keys_str_mv | AT henrotcaroline signalstriggeringprophageinductioninthegutmicrobiota AT petitmarieagnes signalstriggeringprophageinductioninthegutmicrobiota |