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Signals triggering prophage induction in the gut microbiota

Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying pro...

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Detalles Bibliográficos
Autores principales: Henrot, Caroline, Petit, Marie‐Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827884/
https://www.ncbi.nlm.nih.gov/pubmed/36164818
http://dx.doi.org/10.1111/mmi.14983
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author Henrot, Caroline
Petit, Marie‐Agnès
author_facet Henrot, Caroline
Petit, Marie‐Agnès
author_sort Henrot, Caroline
collection PubMed
description Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying prophages. In addition, prophage induction rates are higher in the gut than in vitro. However, studies on the signals leading to prophage induction have essentially focused on genotoxic agents with poor relevance for this environment. In this review, we sum up recent findings about signals able to trigger prophage induction in the gut. Three categories of signals are at play: those originating from interactions between intestinal microbes, those from the human or animal host physiology and those from external intakes. These recent results highlight the diversity of factors influencing prophage induction in the gut, and start to unveil ways by which microbiota composition may be modulated.
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spelling pubmed-98278842023-01-10 Signals triggering prophage induction in the gut microbiota Henrot, Caroline Petit, Marie‐Agnès Mol Microbiol Micro Reviews Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised, and their physiological importance is far less known. Temperate phages are probably a major actor in the gut, as it is estimated that 80% of intestinal bacteria are lysogens, meaning that they are carrying prophages. In addition, prophage induction rates are higher in the gut than in vitro. However, studies on the signals leading to prophage induction have essentially focused on genotoxic agents with poor relevance for this environment. In this review, we sum up recent findings about signals able to trigger prophage induction in the gut. Three categories of signals are at play: those originating from interactions between intestinal microbes, those from the human or animal host physiology and those from external intakes. These recent results highlight the diversity of factors influencing prophage induction in the gut, and start to unveil ways by which microbiota composition may be modulated. John Wiley and Sons Inc. 2022-10-18 2022-11 /pmc/articles/PMC9827884/ /pubmed/36164818 http://dx.doi.org/10.1111/mmi.14983 Text en © 2022 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Micro Reviews
Henrot, Caroline
Petit, Marie‐Agnès
Signals triggering prophage induction in the gut microbiota
title Signals triggering prophage induction in the gut microbiota
title_full Signals triggering prophage induction in the gut microbiota
title_fullStr Signals triggering prophage induction in the gut microbiota
title_full_unstemmed Signals triggering prophage induction in the gut microbiota
title_short Signals triggering prophage induction in the gut microbiota
title_sort signals triggering prophage induction in the gut microbiota
topic Micro Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827884/
https://www.ncbi.nlm.nih.gov/pubmed/36164818
http://dx.doi.org/10.1111/mmi.14983
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