Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo : Methyl 3,4-dihydroxybenzoate inhibits osteoclastogenesis

Osteoporosis deteriorates bone mass and biomechanical strength and is life-threatening to the elderly. In this study, we show that methyl 3,4-dihydroxybenzoate (MDHB), an antioxidant small-molecule compound extracted from natural plants, inhibits receptor activator of nuclear factor-κB (NF-κB) ligan...

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Detalles Bibliográficos
Autores principales: Huang, Zhaobo, Jiang, Zenghui, Zheng, Zeyu, Zhang, Xuyang, Wei, Xiaoan, Chen, Jian, Zhao, Fengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827904/
https://www.ncbi.nlm.nih.gov/pubmed/35929596
http://dx.doi.org/10.3724/abbs.2022087

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