Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2

New antimalarial treatments with novel mechanism of action are needed to tackle Plasmodium falciparum infections that are resistant to first‐line therapeutics. Here we report the exploration of MMV692140 (2) from the Pathogen Box, a collection of 400 compounds that was made available by Medicines fo...

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Detalles Bibliográficos
Autores principales: Laleu, Benoît, Rubiano, Kelly, Yeo, Tomas, Hallyburton, Irene, Anderson, Mark, Crespo‐Fernandez, Benigno, Gamo, Francisco‐Javier, Antonova‐Koch, Yevgeniya, Orjuela‐Sanchez, Pamela, Wittlin, Sergio, Jana, Gouranga P., Maity, Bikash C., Chenu, Elodie, Duffy, James, Sjö, Peter, Waterson, David, Winzeler, Elizabeth, Guantai, Eric, Fidock, David A., Hansson, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827907/
https://www.ncbi.nlm.nih.gov/pubmed/36129427
http://dx.doi.org/10.1002/cmdc.202200393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827907/
https://www.ncbi.nlm.nih.gov/pubmed/36129427
http://dx.doi.org/10.1002/cmdc.202200393

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