Cargando…

Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2

New antimalarial treatments with novel mechanism of action are needed to tackle Plasmodium falciparum infections that are resistant to first‐line therapeutics. Here we report the exploration of MMV692140 (2) from the Pathogen Box, a collection of 400 compounds that was made available by Medicines fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laleu, Benoît, Rubiano, Kelly, Yeo, Tomas, Hallyburton, Irene, Anderson, Mark, Crespo‐Fernandez, Benigno, Gamo, Francisco‐Javier, Antonova‐Koch, Yevgeniya, Orjuela‐Sanchez, Pamela, Wittlin, Sergio, Jana, Gouranga P., Maity, Bikash C., Chenu, Elodie, Duffy, James, Sjö, Peter, Waterson, David, Winzeler, Elizabeth, Guantai, Eric, Fidock, David A., Hansson, Thomas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827907/ https://www.ncbi.nlm.nih.gov/pubmed/36129427 http://dx.doi.org/10.1002/cmdc.202200393

Ejemplares similares

Primary failure of eruption (PFE): a systematic review
por: Hanisch, Marcel, et al.
Publicado: (2018)

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
por: Kümpornsin, Krittikorn, et al.
Publicado: (2023)

Fused Tetrahydroquinolines Are Interfering with Your Assay
por: Bashore, Frances M., et al.
Publicado: (2023)

Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications
por: Andersen, Michael Aagaard, et al.
Publicado: (2019)

The Esterase PfeE, the Achilles’ Heel in the Battle for Iron between Pseudomonas aeruginosa and Escherichia coli
por: Gasser, Véronique, et al.
Publicado: (2021)

Validating clinical characteristics of primary failure of eruption (PFE) associated with PTH1R variants
por: Grippaudo, Cristina, et al.
Publicado: (2021)

Substituted Aminoacetamides as Novel Leads for Malaria Treatment
por: Norcross, Neil R., et al.
Publicado: (2019)

Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench
por: Carter, Nicholas, et al.
Publicado: (2017)

Structure–Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors
por: Sonawane, Yogesh A., et al.
Publicado: (2017)

Experimental and Theoretical Approaches in the Study of Phenanthroline‐Tetrahydroquinolines for Alzheimer's Disease
por: Duarte, Yorley, et al.
Publicado: (2019)

Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
por: Ryczkowska, Małgorzata, et al.
Publicado: (2022)

Ligand-dependent, palladium-catalyzed stereodivergent synthesis of chiral tetrahydroquinolines
por: Wang, Yue, et al.
Publicado: (2022)

Synthesis of hybrid hydrophobic composite air filtration membranes for antibacterial activity and chemical detoxification with high particulate filtration efficiency (PFE)
por: Vanangamudi, Anbharasi, et al.
Publicado: (2015)

Choosing the Right Treatment Option for the Right R/M HNSCC Patient: Should We Adhere to PFE for First-Line Therapy?
por: Lübbers, Katharina, et al.
Publicado: (2021)

5,6,7,8-Tetrahydroquinolin-8-one
por: Lipińska, Teodozja M., et al.
Publicado: (2011)

Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline
por: Fathy, Usama, et al.
Publicado: (2021)

A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones
por: Liu, Wei, et al.
Publicado: (2021)

Electrostatic self-assembly of pFe(3)O(4) nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds
por: Yang, Wenjing, et al.
Publicado: (2020)

Safety, tolerability, and antibody response after intradermal vaccination of PFE-BNT in adults who have completed two-doses of Verocell (inactivated vaccine)
por: Chalermphanchai, Nipon, et al.
Publicado: (2022)

5,6,7,8-Tetrahydroquinoline 1-oxide hemihydrate
por: Karczmarzyk, Zbigniew, et al.
Publicado: (2010)

Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
por: Wendlandt, Alison E., et al.
Publicado: (2014)

5-Oxo-hexahydroquinoline Derivatives and Their Tetrahydroquinoline Counterparts as Multidrug Resistance Reversal Agents
por: Shahraki, Omolbanin, et al.
Publicado: (2020)

A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines
por: Lázaro‐Milla, Carlos, et al.
Publicado: (2021)

Synthesis of Novel Spiro-Tetrahydroquinoline Derivatives and Evaluation of Their Pharmacological Effects on Wound Healing
por: Liou, Yan-Cheng, et al.
Publicado: (2021)

Bis(1,2,3,4-tetrahydroquinolin-6-yl)methane
por: Shen, Li, et al.
Publicado: (2008)

A combined continuous microflow photochemistry and asymmetric organocatalysis approach for the enantioselective synthesis of tetrahydroquinolines
por: Sugiono, Erli, et al.
Publicado: (2013)

Crystal structure of 1-tosyl-1,2,3,4-tetrahydroquinoline
por: Jeyaseelan, S., et al.
Publicado: (2014)

Preparation of Half- and Post-Metallocene Hafnium Complexes with Tetrahydroquinoline and Tetrahydrophenanthroline Frameworks for Olefin Polymerization
por: Baek, Jun Won, et al.
Publicado: (2019)

Synthesis and fungicidal activity of pyrazole derivatives containing 1,2,3,4-tetrahydroquinoline
por: Lei, Peng, et al.
Publicado: (2016)

Aerobic Oxidative EDA Catalysis: Synthesis of Tetrahydroquinolines Using an Organocatalytic EDA Active Acceptor
por: Runemark, August, et al.
Publicado: (2022)

The Role of the Conjugate Bridge in Electronic Structures and Related Properties of Tetrahydroquinoline for Dye Sensitized Solar Cells
por: Zhang, Cai-Rong, et al.
Publicado: (2013)

Crystal structure of 1-benzylsulfonyl-1,2,3,4-tetrahydroquinoline
por: Jeyaseelan, S., et al.
Publicado: (2015)

Crystal structure of 1-methanesulfonyl-1,2,3,4-tetrahydroquinoline
por: Jeyaseelan, S., et al.
Publicado: (2015)

Gold-Catalyzed Hydroalkoxylation/Povarov Reaction Cascade of Alkynols with N-Aryl Imines: Synthesis of Tetrahydroquinolines
por: He, Ciwang, et al.
Publicado: (2019)

Receptor-binding affinity and larvicidal activity of tetrahydroquinoline-type ecdysone agonists against Aedes albopictus
por: Ueno, Minori, et al.
Publicado: (2021)

Syntheses of tetrahydroquinoline-based chiral carbene precursors and the related chiral NHC–Au(i) complex
por: Zhan, Licheng, et al.
Publicado: (2020)

Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael–Michael addition
por: Palanimuthu, Arunan, et al.
Publicado: (2020)

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation
por: Fennell, Clare, et al.
Publicado: (2009)

Mortality and Morbidity in HFrEF, HFmrEF, and HFpEF Patients with Diabetes in the Middle East
por: Al-Jarallah, Mohammed, et al.
Publicado: (2020)

Similarities and Differences Between HFmrEF and HFpEF
por: Li, Peixin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f7ps3ob37fr7p9et7ldilknk75