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Postexposure‐vaccine‐prophylaxis against COVID‐19

During the COVID‐19 pandemic, postexposure‐vaccine‐prophylaxis is not a practice. Following exposure, only patient isolation is imposed. Moreover, no therapeutic prevention approach is applied. We asked whether evidence exists for reduced mortality rate following postexposure‐vaccine‐prophylaxis. To...

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Autores principales: Shmuelian, Zohar, Warszawer, Yehuda, Or, Omri, Arbel‐Alon, Sagit, Giladi, Hilla, Avgil Tsadok, Meytal, Cohen, Roy, Shefer, Galit, Shlomi, Dekel, Hoshen, Moshe, Maruotti, Antonello, Jona‐Lasinio, Giovanna, Galun, Eithan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827940/
https://www.ncbi.nlm.nih.gov/pubmed/36324272
http://dx.doi.org/10.1002/jmv.28274
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author Shmuelian, Zohar
Warszawer, Yehuda
Or, Omri
Arbel‐Alon, Sagit
Giladi, Hilla
Avgil Tsadok, Meytal
Cohen, Roy
Shefer, Galit
Shlomi, Dekel
Hoshen, Moshe
Maruotti, Antonello
Jona‐Lasinio, Giovanna
Galun, Eithan
author_facet Shmuelian, Zohar
Warszawer, Yehuda
Or, Omri
Arbel‐Alon, Sagit
Giladi, Hilla
Avgil Tsadok, Meytal
Cohen, Roy
Shefer, Galit
Shlomi, Dekel
Hoshen, Moshe
Maruotti, Antonello
Jona‐Lasinio, Giovanna
Galun, Eithan
author_sort Shmuelian, Zohar
collection PubMed
description During the COVID‐19 pandemic, postexposure‐vaccine‐prophylaxis is not a practice. Following exposure, only patient isolation is imposed. Moreover, no therapeutic prevention approach is applied. We asked whether evidence exists for reduced mortality rate following postexposure‐vaccine‐prophylaxis. To estimate the effectiveness of postexposure‐vaccine‐prophylaxis, we obtained data from the Israeli Ministry of Health registry. The study population consisted of Israeli residents aged 12 years and older, identified for the first time as PCR‐positive for SARS‐CoV‐2, between December 20th, 2020 (the beginning of the vaccination campaign) and October 7th, 2021. We compared “recently injected” patients—that proved PCR‐positive on the same day or on 1 of the 5 consecutive days after first vaccination (representing an unintended postexposure‐vaccine‐prophylaxis)s—to unvaccinated control group. Among Israeli residents identified PCR‐positive for SARS‐CoV‐2, 11 687 were found positive on the day they received their first vaccine injection (BNT162b2) or on 1 of the 5 days thereafter. In patients over 65 years, 143 deaths occurred among 1412 recently injected (10.13%) compared to 255 deaths among the 1412 unvaccinated (18.06%), odd ratio (OR) 0.51 (95% confidence interval [CI]: 0.41–0.64; p < 0.001). A significant reduction in the death toll was observed among the 55–64 age group, with 8 deaths occurring among the 1320 recently injected (0.61%) compared to 24 deaths among the 1320 unvaccinated control (1.82%), OR 0.33 (95% CI: 0.13–0.76; p = 0.007). Postexposure‐vaccine‐prophylaxis is effective against death in COVID‐19 infection.
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spelling pubmed-98279402023-01-10 Postexposure‐vaccine‐prophylaxis against COVID‐19 Shmuelian, Zohar Warszawer, Yehuda Or, Omri Arbel‐Alon, Sagit Giladi, Hilla Avgil Tsadok, Meytal Cohen, Roy Shefer, Galit Shlomi, Dekel Hoshen, Moshe Maruotti, Antonello Jona‐Lasinio, Giovanna Galun, Eithan J Med Virol Research Articles During the COVID‐19 pandemic, postexposure‐vaccine‐prophylaxis is not a practice. Following exposure, only patient isolation is imposed. Moreover, no therapeutic prevention approach is applied. We asked whether evidence exists for reduced mortality rate following postexposure‐vaccine‐prophylaxis. To estimate the effectiveness of postexposure‐vaccine‐prophylaxis, we obtained data from the Israeli Ministry of Health registry. The study population consisted of Israeli residents aged 12 years and older, identified for the first time as PCR‐positive for SARS‐CoV‐2, between December 20th, 2020 (the beginning of the vaccination campaign) and October 7th, 2021. We compared “recently injected” patients—that proved PCR‐positive on the same day or on 1 of the 5 consecutive days after first vaccination (representing an unintended postexposure‐vaccine‐prophylaxis)s—to unvaccinated control group. Among Israeli residents identified PCR‐positive for SARS‐CoV‐2, 11 687 were found positive on the day they received their first vaccine injection (BNT162b2) or on 1 of the 5 days thereafter. In patients over 65 years, 143 deaths occurred among 1412 recently injected (10.13%) compared to 255 deaths among the 1412 unvaccinated (18.06%), odd ratio (OR) 0.51 (95% confidence interval [CI]: 0.41–0.64; p < 0.001). A significant reduction in the death toll was observed among the 55–64 age group, with 8 deaths occurring among the 1320 recently injected (0.61%) compared to 24 deaths among the 1320 unvaccinated control (1.82%), OR 0.33 (95% CI: 0.13–0.76; p = 0.007). Postexposure‐vaccine‐prophylaxis is effective against death in COVID‐19 infection. John Wiley and Sons Inc. 2022-11-11 2023-01 /pmc/articles/PMC9827940/ /pubmed/36324272 http://dx.doi.org/10.1002/jmv.28274 Text en © 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Shmuelian, Zohar
Warszawer, Yehuda
Or, Omri
Arbel‐Alon, Sagit
Giladi, Hilla
Avgil Tsadok, Meytal
Cohen, Roy
Shefer, Galit
Shlomi, Dekel
Hoshen, Moshe
Maruotti, Antonello
Jona‐Lasinio, Giovanna
Galun, Eithan
Postexposure‐vaccine‐prophylaxis against COVID‐19
title Postexposure‐vaccine‐prophylaxis against COVID‐19
title_full Postexposure‐vaccine‐prophylaxis against COVID‐19
title_fullStr Postexposure‐vaccine‐prophylaxis against COVID‐19
title_full_unstemmed Postexposure‐vaccine‐prophylaxis against COVID‐19
title_short Postexposure‐vaccine‐prophylaxis against COVID‐19
title_sort postexposure‐vaccine‐prophylaxis against covid‐19
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827940/
https://www.ncbi.nlm.nih.gov/pubmed/36324272
http://dx.doi.org/10.1002/jmv.28274
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