PHD3 inhibits cell proliferation through hydroxylation of PAX2 at proline 9: PHD3 hydroxylates PAX2

The oncoprotein transcription factor paired box 2 (PAX2) is aberrantly expressed in cancers, but the underlying mechanism remains elusive. Prolyl hydroxylase 3 (PHD3) hydroxylates the proline residue of HIFα, mediating HIFα degradation. The von Hippel-Lindau protein (pVHL) is an E3 ligase which medi...

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Detalles Bibliográficos
Autores principales: Lun, Jie, Wang, Yuxin, Gao, Qiang, Wang, Yu, Zhang, Hongwei, Fang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827955/
https://www.ncbi.nlm.nih.gov/pubmed/35920196
http://dx.doi.org/10.3724/abbs.2022043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827955/
https://www.ncbi.nlm.nih.gov/pubmed/35920196
http://dx.doi.org/10.3724/abbs.2022043

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