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Germline gain‐of‐function MMP11 variant results in an aggressive form of colorectal cancer

Matrix metalloproteinase‐11 (MMP11) is an enzyme with proteolytic activity against matrix and nonmatrix proteins. Although most MMPs are secreted as inactive proenzymes and are later activated extracellularly, MMP11 is activated intracellularly by furin within the constitutive secretory pathway. It...

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Detalles Bibliográficos
Autores principales:	Martin‐Morales, Lorena, Manzano, Sara, Rodrigo‐Faus, Maria, Vicente‐Barrueco, Adrian, Lorca, Victor, Núñez‐Moreno, Gonzalo, Bragado, Paloma, Porras, Almudena, Caldes, Trinidad, Garre, Pilar, Gutierrez‐Uzquiza, Alvaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Molecular Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827992/ https://www.ncbi.nlm.nih.gov/pubmed/36093604 http://dx.doi.org/10.1002/ijc.34289

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