Cargando…
International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence
OBJECTIVE: This study was undertaken to develop consensus‐based recommendations for the management of adult and pediatric patients with new onset refractory status epilepticus (NORSE)/febrile infection‐related epilepsy syndrome (FIRES) based on best evidence and experience. METHODS: The Delphi metho...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828002/ https://www.ncbi.nlm.nih.gov/pubmed/35997591 http://dx.doi.org/10.1111/epi.17397 |
_version_ | 1784867171946463232 |
---|---|
author | Wickstrom, Ronny Taraschenko, Olga Dilena, Robertino Payne, Eric T. Specchio, Nicola Nabbout, Rima Koh, Sookyong Gaspard, Nicolas Hirsch, Lawrence J. Auvin, Stephane van Baalen, Andreas Beghi, Ettore Benseler, Susanne M. Bergin, Peter Bleck, Tom Brunklaus, Andreas Caraballo, Roberto H. Cervenka, Mackenzie Costello, Daniel Drislane, Frank Farias‐Moeller, Raquel Gallantine, William Gilmore, Emily Gofton, Teneille Jimenez, Maria Angeles Perez Hocker, Sara Kaliakatsos, Marios Kellogg, Marissa Lee, Jong Woo Loddenkemper, Tobias Meletti, Stefano Mizugushi, Masashi Muscal, Eyal Riviello, James J. Rosenthal, Eric S. Rossetti, Andrea O. Ruegg, Stefan Said, Rana Sculier, Claudine Schmitt, Sarah Schuele, Stephan Stredny, Coral Trinka, Eugen Wainwright, Mark VanHaerents, Stephen Wells, Elisabeth Wirrell, Elaine Zuberi, Sameer M. |
author_facet | Wickstrom, Ronny Taraschenko, Olga Dilena, Robertino Payne, Eric T. Specchio, Nicola Nabbout, Rima Koh, Sookyong Gaspard, Nicolas Hirsch, Lawrence J. Auvin, Stephane van Baalen, Andreas Beghi, Ettore Benseler, Susanne M. Bergin, Peter Bleck, Tom Brunklaus, Andreas Caraballo, Roberto H. Cervenka, Mackenzie Costello, Daniel Drislane, Frank Farias‐Moeller, Raquel Gallantine, William Gilmore, Emily Gofton, Teneille Jimenez, Maria Angeles Perez Hocker, Sara Kaliakatsos, Marios Kellogg, Marissa Lee, Jong Woo Loddenkemper, Tobias Meletti, Stefano Mizugushi, Masashi Muscal, Eyal Riviello, James J. Rosenthal, Eric S. Rossetti, Andrea O. Ruegg, Stefan Said, Rana Sculier, Claudine Schmitt, Sarah Schuele, Stephan Stredny, Coral Trinka, Eugen Wainwright, Mark VanHaerents, Stephen Wells, Elisabeth Wirrell, Elaine Zuberi, Sameer M. |
author_sort | Wickstrom, Ronny |
collection | PubMed |
description | OBJECTIVE: This study was undertaken to develop consensus‐based recommendations for the management of adult and pediatric patients with new onset refractory status epilepticus (NORSE)/febrile infection‐related epilepsy syndrome (FIRES) based on best evidence and experience. METHODS: The Delphi methodology was followed. A facilitator group of nine experts was established, who defined the scope, users, and suggestions for recommendations. Following a review of the current literature, recommendation statements concerning diagnosis, treatment, and research directions were generated, which were then rated on a scale of 1 (strongly disagree) to 9 (strongly agree) by a panel of 48 experts in the field. Consensus that a statement was appropriate was reached if the median score was ≥7 and inappropriate if the median score was ≤3. The analysis of evidence was mapped to the results of each statement included in the Delphi survey. RESULTS: Overall, 85 recommendation statements achieved consensus. The recommendations are divided into five sections: (1) disease characteristics; (2) diagnostic testing and sampling; (3) acute treatment; (4) treatment in the postacute phase; and (5) research, registries, and future directions in NORSE/FIRES. The detailed results and discussion of all 85 statements are outlined herein. A corresponding summary of findings and practical flowsheets are presented in a companion article. SIGNIFICANCE: This detailed analysis offers insight into the supporting evidence and the current gaps in the literature that are associated with expert consensus statements related to NORSE/FIRES. The recommendations generated by this consensus can be used as a guide for the diagnosis, evaluation, and management of patients with NORSE/FIRES, and for planning of future research. |
format | Online Article Text |
id | pubmed-9828002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98280022023-01-10 International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence Wickstrom, Ronny Taraschenko, Olga Dilena, Robertino Payne, Eric T. Specchio, Nicola Nabbout, Rima Koh, Sookyong Gaspard, Nicolas Hirsch, Lawrence J. Auvin, Stephane van Baalen, Andreas Beghi, Ettore Benseler, Susanne M. Bergin, Peter Bleck, Tom Brunklaus, Andreas Caraballo, Roberto H. Cervenka, Mackenzie Costello, Daniel Drislane, Frank Farias‐Moeller, Raquel Gallantine, William Gilmore, Emily Gofton, Teneille Jimenez, Maria Angeles Perez Hocker, Sara Kaliakatsos, Marios Kellogg, Marissa Lee, Jong Woo Loddenkemper, Tobias Meletti, Stefano Mizugushi, Masashi Muscal, Eyal Riviello, James J. Rosenthal, Eric S. Rossetti, Andrea O. Ruegg, Stefan Said, Rana Sculier, Claudine Schmitt, Sarah Schuele, Stephan Stredny, Coral Trinka, Eugen Wainwright, Mark VanHaerents, Stephen Wells, Elisabeth Wirrell, Elaine Zuberi, Sameer M. Epilepsia Special Reports OBJECTIVE: This study was undertaken to develop consensus‐based recommendations for the management of adult and pediatric patients with new onset refractory status epilepticus (NORSE)/febrile infection‐related epilepsy syndrome (FIRES) based on best evidence and experience. METHODS: The Delphi methodology was followed. A facilitator group of nine experts was established, who defined the scope, users, and suggestions for recommendations. Following a review of the current literature, recommendation statements concerning diagnosis, treatment, and research directions were generated, which were then rated on a scale of 1 (strongly disagree) to 9 (strongly agree) by a panel of 48 experts in the field. Consensus that a statement was appropriate was reached if the median score was ≥7 and inappropriate if the median score was ≤3. The analysis of evidence was mapped to the results of each statement included in the Delphi survey. RESULTS: Overall, 85 recommendation statements achieved consensus. The recommendations are divided into five sections: (1) disease characteristics; (2) diagnostic testing and sampling; (3) acute treatment; (4) treatment in the postacute phase; and (5) research, registries, and future directions in NORSE/FIRES. The detailed results and discussion of all 85 statements are outlined herein. A corresponding summary of findings and practical flowsheets are presented in a companion article. SIGNIFICANCE: This detailed analysis offers insight into the supporting evidence and the current gaps in the literature that are associated with expert consensus statements related to NORSE/FIRES. The recommendations generated by this consensus can be used as a guide for the diagnosis, evaluation, and management of patients with NORSE/FIRES, and for planning of future research. John Wiley and Sons Inc. 2022-09-27 2022-11 /pmc/articles/PMC9828002/ /pubmed/35997591 http://dx.doi.org/10.1111/epi.17397 Text en © 2022 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Special Reports Wickstrom, Ronny Taraschenko, Olga Dilena, Robertino Payne, Eric T. Specchio, Nicola Nabbout, Rima Koh, Sookyong Gaspard, Nicolas Hirsch, Lawrence J. Auvin, Stephane van Baalen, Andreas Beghi, Ettore Benseler, Susanne M. Bergin, Peter Bleck, Tom Brunklaus, Andreas Caraballo, Roberto H. Cervenka, Mackenzie Costello, Daniel Drislane, Frank Farias‐Moeller, Raquel Gallantine, William Gilmore, Emily Gofton, Teneille Jimenez, Maria Angeles Perez Hocker, Sara Kaliakatsos, Marios Kellogg, Marissa Lee, Jong Woo Loddenkemper, Tobias Meletti, Stefano Mizugushi, Masashi Muscal, Eyal Riviello, James J. Rosenthal, Eric S. Rossetti, Andrea O. Ruegg, Stefan Said, Rana Sculier, Claudine Schmitt, Sarah Schuele, Stephan Stredny, Coral Trinka, Eugen Wainwright, Mark VanHaerents, Stephen Wells, Elisabeth Wirrell, Elaine Zuberi, Sameer M. International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence |
title | International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence |
title_full | International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence |
title_fullStr | International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence |
title_full_unstemmed | International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence |
title_short | International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: Statements and supporting evidence |
title_sort | international consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome: statements and supporting evidence |
topic | Special Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828002/ https://www.ncbi.nlm.nih.gov/pubmed/35997591 http://dx.doi.org/10.1111/epi.17397 |
work_keys_str_mv | AT wickstromronny internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT taraschenkoolga internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT dilenarobertino internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT payneerict internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT specchionicola internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT nabboutrima internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT kohsookyong internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT gaspardnicolas internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT hirschlawrencej internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT auvinstephane internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT vanbaalenandreas internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT beghiettore internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT benselersusannem internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT berginpeter internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT blecktom internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT brunklausandreas internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT caraballorobertoh internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT cervenkamackenzie internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT costellodaniel internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT drislanefrank internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT fariasmoellerraquel internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT gallantinewilliam internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT gilmoreemily internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT goftonteneille internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT jimenezmariaangelesperez internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT hockersara internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT kaliakatsosmarios internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT kelloggmarissa internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT leejongwoo internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT loddenkempertobias internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT melettistefano internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT mizugushimasashi internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT muscaleyal internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT riviellojamesj internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT rosenthalerics internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT rossettiandreao internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT rueggstefan internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT saidrana internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT sculierclaudine internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT schmittsarah internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT schuelestephan internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT strednycoral internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT trinkaeugen internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT wainwrightmark internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT vanhaerentsstephen internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT wellselisabeth internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT wirrellelaine internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence AT zuberisameerm internationalconsensusrecommendationsformanagementofnewonsetrefractorystatusepilepticusincludingfebrileinfectionrelatedepilepsysyndromestatementsandsupportingevidence |