Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells: CBX4 overexpression inhibits TNF-α-induced matrix catabolism and senescence

Intervertebral disc degeneration (IDD) is featured as enhanced catabolism of extracellular matrix (ECM) in the nucleus pulposus (NP), in which tumor necrosis factor-alpha (TNF-α)-related cell senescence is involved. Chromobox homolog protein 4 (CBX4) exhibits anti-inflammatory effects and shows prom...

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Detalles Bibliográficos
Autores principales: Zhang, Yangyang, Li, Shuangxing, Hong, Junmin, Yan, Jiansen, Huang, Zhengqi, Wu, Jiajun, Deng, Zhihuai, Qin, Tianyu, Xu, Kang, Ye, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828005/
https://www.ncbi.nlm.nih.gov/pubmed/35880565
http://dx.doi.org/10.3724/abbs.2022063

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