Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome

OBJECTIVE: Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary Sjögren's syndrome (SS) has not been studied systematically. This study was u...

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Detalles Bibliográficos
Autores principales: Lundtoft, Christian, Sjöwall, Christopher, Rantapää‐Dahlqvist, Solbritt, Bengtsson, Anders A., Jönsen, Andreas, Pucholt, Pascal, Wu, Yee Ling, Lundström, Emeli, Eloranta, Maija‐Leena, Gunnarsson, Iva, Baecklund, Eva, Jonsson, Roland, Hammenfors, Daniel, Forsblad‐d'Elia, Helena, Eriksson, Per, Mandl, Thomas, Bucher, Sara, Norheim, Katrine B., Auglaend Johnsen, Svein Joar, Omdal, Roald, Kvarnström, Marika, Wahren‐Herlenius, Marie, Truedsson, Lennart, Nilsson, Bo, Kozyrev, Sergey V., Bianchi, Matteo, Lindblad‐Toh, Kerstin, Yu, Chack‐Yung, Nordmark, Gunnel, Sandling, Johanna K., Svenungsson, Elisabet, Leonard, Dag, Rönnblom, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2022
Materias:
Sjögren's Syndrome
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828039/
https://www.ncbi.nlm.nih.gov/pubmed/35729719
http://dx.doi.org/10.1002/art.42270

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