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Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes

The prevalence of a high‐energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumu...

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Autores principales: Chang, Wenguang, Wang, Man, Zhang, Yuan, Yu, Fei, Hu, Bin, Goljanek‐Whysall, Katarzyna, Li, Peifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828071/
https://www.ncbi.nlm.nih.gov/pubmed/36109347
http://dx.doi.org/10.1111/tra.12868
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author Chang, Wenguang
Wang, Man
Zhang, Yuan
Yu, Fei
Hu, Bin
Goljanek‐Whysall, Katarzyna
Li, Peifeng
author_facet Chang, Wenguang
Wang, Man
Zhang, Yuan
Yu, Fei
Hu, Bin
Goljanek‐Whysall, Katarzyna
Li, Peifeng
author_sort Chang, Wenguang
collection PubMed
description The prevalence of a high‐energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future.
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spelling pubmed-98280712023-01-10 Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes Chang, Wenguang Wang, Man Zhang, Yuan Yu, Fei Hu, Bin Goljanek‐Whysall, Katarzyna Li, Peifeng Traffic Review The prevalence of a high‐energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future. John Wiley & Sons A/S 2022-09-26 2022-11 /pmc/articles/PMC9828071/ /pubmed/36109347 http://dx.doi.org/10.1111/tra.12868 Text en © 2022 The Authors. Traffic published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Chang, Wenguang
Wang, Man
Zhang, Yuan
Yu, Fei
Hu, Bin
Goljanek‐Whysall, Katarzyna
Li, Peifeng
Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes
title Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes
title_full Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes
title_fullStr Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes
title_full_unstemmed Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes
title_short Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes
title_sort roles of long noncoding rnas and small extracellular vesicle‐long noncoding rnas in type 2 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828071/
https://www.ncbi.nlm.nih.gov/pubmed/36109347
http://dx.doi.org/10.1111/tra.12868
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