Temperature‐Controlled Mechanochemistry for the Nickel‐Catalyzed Suzuki–Miyaura‐Type Coupling of Aryl Sulfamates via Ball Milling and Twin‐Screw Extrusion.

The nickel catalyzed Suzuki–Miyaura‐type coupling of aryl sulfamates and boronic acid derivatives enabled by temperature‐controlled mechanochemistry via the development of a programmable PID‐controlled jar heater is reported. This base‐metal‐catalyzed, solvent‐free, all‐under‐air protocol was also s...

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Detalles Bibliográficos
Autores principales: Bolt, Robert R. A., Raby‐Buck, Sarah E., Ingram, Katharine, Leitch, Jamie A., Browne, Duncan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828252/
https://www.ncbi.nlm.nih.gov/pubmed/36082766
http://dx.doi.org/10.1002/anie.202210508
Descripción
Sumario:The nickel catalyzed Suzuki–Miyaura‐type coupling of aryl sulfamates and boronic acid derivatives enabled by temperature‐controlled mechanochemistry via the development of a programmable PID‐controlled jar heater is reported. This base‐metal‐catalyzed, solvent‐free, all‐under‐air protocol was also scaled 200‐fold using twin‐screw extrusion technology affording decagram quantities of material.[Image: see text]

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