Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii

Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathog...

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Detalles Bibliográficos
Autores principales: Huang, Yemei, Zang, Xuelei, Yang, Chen, Deng, Hengyu, Ma, Xidong, Xie, Mei, Zhou, Meng, Song, Jialin, Xue, Xinying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828318/
https://www.ncbi.nlm.nih.gov/pubmed/35593469
http://dx.doi.org/10.3724/abbs.2022029
Descripción
Sumario:Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how C. gattii causes disease and to characterize hypervirulent C. gattii strains, we summarize the current understanding of C. gattii genotypes, phenotypes, virulence, and the regulatory mechanisms.

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