Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii

Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathog...

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Autores principales: Huang, Yemei, Zang, Xuelei, Yang, Chen, Deng, Hengyu, Ma, Xidong, Xie, Mei, Zhou, Meng, Song, Jialin, Xue, Xinying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828318/
https://www.ncbi.nlm.nih.gov/pubmed/35593469
http://dx.doi.org/10.3724/abbs.2022029
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author Huang, Yemei
Zang, Xuelei
Yang, Chen
Deng, Hengyu
Ma, Xidong
Xie, Mei
Zhou, Meng
Song, Jialin
Xue, Xinying
author_facet Huang, Yemei
Zang, Xuelei
Yang, Chen
Deng, Hengyu
Ma, Xidong
Xie, Mei
Zhou, Meng
Song, Jialin
Xue, Xinying
author_sort Huang, Yemei
collection PubMed
description Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how C. gattii causes disease and to characterize hypervirulent C. gattii strains, we summarize the current understanding of C. gattii genotypes, phenotypes, virulence, and the regulatory mechanisms.
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spelling pubmed-98283182023-02-10 Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii Huang, Yemei Zang, Xuelei Yang, Chen Deng, Hengyu Ma, Xidong Xie, Mei Zhou, Meng Song, Jialin Xue, Xinying Acta Biochim Biophys Sin (Shanghai) Research Article Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how C. gattii causes disease and to characterize hypervirulent C. gattii strains, we summarize the current understanding of C. gattii genotypes, phenotypes, virulence, and the regulatory mechanisms. Oxford University Press 2022-03-25 /pmc/articles/PMC9828318/ /pubmed/35593469 http://dx.doi.org/10.3724/abbs.2022029 Text en © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Huang, Yemei
Zang, Xuelei
Yang, Chen
Deng, Hengyu
Ma, Xidong
Xie, Mei
Zhou, Meng
Song, Jialin
Xue, Xinying
Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii
title Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii
title_full Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii
title_fullStr Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii
title_full_unstemmed Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii
title_short Gene, virulence and related regulatory mechanisms in Cryptococcus gattii : Gene, virulence and regulatory mechanisms in C. gattii
title_sort gene, virulence and related regulatory mechanisms in cryptococcus gattii : gene, virulence and regulatory mechanisms in c. gattii
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828318/
https://www.ncbi.nlm.nih.gov/pubmed/35593469
http://dx.doi.org/10.3724/abbs.2022029
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